Gene description for Slc1a1
Gene name	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Gene symbol	Slc1a1
Other names/aliases	Eaac1 Eaat3 REAAC1
Species	Rattus norvegicus
Database cross references - Slc1a1
ExoCarta	ExoCarta_25550
Vesiclepedia	VP_25550
Entrez Gene	25550
UniProt	P51907
Slc1a1 identified in sEVs derived from the following tissue/cell type
Urine	20535238

Gene ontology annotations for Slc1a1

Molecular Function     monoatomic anion channel activity GO:0005253 ISO     L-glutamate transmembrane transporter activity GO:0005313 IBA     L-glutamate transmembrane transporter activity GO:0005313 IDA     L-glutamate transmembrane transporter activity GO:0005313 ISO     high-affinity L-glutamate transmembrane transporter activity GO:0005314 ISO     high-affinity L-glutamate transmembrane transporter activity GO:0005314 ISS     protein binding GO:0005515 IPI     chloride transmembrane transporter activity GO:0015108 ISO     chloride transmembrane transporter activity GO:0015108 ISS     acidic amino acid transmembrane transporter activity GO:0015172 IEA     L-amino acid transmembrane transporter activity GO:0015179 IEA     L-aspartate transmembrane transporter activity GO:0015183 ISO     symporter activity GO:0015293 IEA     glutamate:sodium symporter activity GO:0015501 IBA     glutamate:sodium symporter activity GO:0015501 IDA     glutamate:sodium symporter activity GO:0015501 ISO     glutamate binding GO:0016595 IDA     cysteine transmembrane transporter activity GO:0033229 IBA     cysteine transmembrane transporter activity GO:0033229 ISO     cysteine transmembrane transporter activity GO:0033229 ISS     identical protein binding GO:0042802 IPI     identical protein binding GO:0042802 ISO     metal ion binding GO:0046872 IEA     D-aspartate transmembrane transporter activity GO:0140010 ISO Biological Process     behavioral fear response GO:0001662 ISO     regulation of protein phosphorylation GO:0001932 ISO     response to amphetamine GO:0001975 ISO     regulation of heart rate GO:0002027 ISO     glutathione metabolic process GO:0006749 ISO     glutathione metabolic process GO:0006749 ISO     glutathione biosynthetic process GO:0006750 ISO     superoxide metabolic process GO:0006801 ISO     intracellular zinc ion homeostasis GO:0006882 ISO     intracellular zinc ion homeostasis GO:0006882 ISO     G protein-coupled dopamine receptor signaling pathway GO:0007212 ISO     glutamate receptor signaling pathway GO:0007215 ISO     brain development GO:0007420 ISO     learning or memory GO:0007611 ISO     memory GO:0007613 ISO     grooming behavior GO:0007625 ISO     locomotory behavior GO:0007626 ISO     response to xenobiotic stimulus GO:0009410 ISO     positive regulation of heart rate GO:0010460 ISO     gene expression GO:0010467 ISO     retina layer formation GO:0010842 ISO     retina layer formation GO:0010842 ISO     L-glutamate transmembrane transport GO:0015813 IBA     L-glutamate transmembrane transport GO:0015813 IDA     L-glutamate transmembrane transport GO:0015813 IEA     L-glutamate transmembrane transport GO:0015813 ISO     L-glutamate transmembrane transport GO:0015813 ISO     peptidyl-serine phosphorylation GO:0018105 ISO     cytokine-mediated signaling pathway GO:0019221 ISO     neurogenesis GO:0022008 ISO     adult behavior GO:0030534 ISO     activation of protein kinase B activity GO:0032148 ISO     cellular response to oxidative stress GO:0034599 ISO     maintenance of blood-brain barrier GO:0035633 ISO     response to decreased oxygen levels GO:0036293 ISO     response to decreased oxygen levels GO:0036293 ISO     dopamine metabolic process GO:0042417 ISO     cysteine transport GO:0042883 ISO     cysteine transport GO:0042883 ISS     response to morphine GO:0043278 ISO     negative regulation of neuron apoptotic process GO:0043524 ISO     establishment of protein localization GO:0045184 ISO     blood vessel morphogenesis GO:0048514 ISO     response to axon injury GO:0048678 ISO     response to axon injury GO:0048678 ISO     synapse organization GO:0050808 ISO     neuron apoptotic process GO:0051402 ISO     L-glutamate import GO:0051938 ISO     righting reflex GO:0060013 ISO     retina development in camera-type eye GO:0060041 ISO     heart contraction GO:0060047 ISO     long-term synaptic potentiation GO:0060291 ISO     long-term synaptic potentiation GO:0060291 ISO     motor behavior GO:0061744 ISO     D-aspartate transmembrane transport GO:0070777 ISO     L-aspartate transmembrane transport GO:0070778 ISO     D-aspartate import across plasma membrane GO:0070779 ISO     cellular response to ammonium ion GO:0071242 ISO     cellular response to mercury ion GO:0071288 ISO     cellular response to cocaine GO:0071314 ISO     cellular response to organic cyclic compound GO:0071407 ISO     zinc ion transmembrane transport GO:0071577 ISO     response to anesthetic GO:0072347 ISO     response to anesthetic GO:0072347 ISO     regulation of protein targeting to membrane GO:0090313 ISO     intracellular glutamate homeostasis GO:0090461 ISO     motor neuron apoptotic process GO:0097049 ISO     L-glutamate import across plasma membrane GO:0098712 ISO     L-glutamate import across plasma membrane GO:0098712 ISO     L-glutamate import across plasma membrane GO:0098712 ISS     neurotransmitter receptor transport to plasma membrane GO:0098877 ISO     postsynaptic modulation of chemical synaptic transmission GO:0099170 ISO     L-aspartate import across plasma membrane GO:0140009 ISO     L-aspartate import across plasma membrane GO:0140009 ISS     chloride transmembrane transport GO:1902476 ISO     chloride transmembrane transport GO:1902476 ISS     cysteine transmembrane transport GO:1903712 ISO     cellular response to bisphenol A GO:1903926 ISO     conditioned place preference GO:1990708 ISO Subcellular Localization     cytoplasm GO:0005737 ISO     endoplasmic reticulum GO:0005783 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     external side of plasma membrane GO:0009897 IDA     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     membrane GO:0016020 IDA     membrane GO:0016020 ISO     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     apical plasma membrane GO:0016324 ISO     apical plasma membrane GO:0016324 ISS     axon GO:0030424 IDA     dendrite GO:0030425 IDA     dendrite GO:0030425 ISO     early endosome membrane GO:0031901 IEA     early endosome membrane GO:0031901 ISO     late endosome membrane GO:0031902 IEA     vesicle GO:0031982 ISO     asymmetric synapse GO:0032279 IDA     neuron projection GO:0043005 IEA     neuronal cell body GO:0043025 IDA     neuronal cell body GO:0043025 ISO     synaptic cleft GO:0043083 IDA     dendritic spine GO:0043197 IDA     dendritic shaft GO:0043198 IDA     perikaryon GO:0043204 IDA     axon terminus GO:0043679 IDA     membrane raft GO:0045121 ISO     synapse GO:0045202 IEA     synapse GO:0045202 ISO     recycling endosome GO:0055037 ISO     recycling endosome membrane GO:0055038 IEA     recycling endosome membrane GO:0055038 ISO     cell periphery GO:0071944 IDA     glial cell projection GO:0097386 IDA     apical dendrite GO:0097440 IDA     Schaffer collateral - CA1 synapse GO:0098685 ISO     presynapse GO:0098793 IDA     perisynaptic space GO:0099544 IDA     distal dendrite GO:0150002 IDA     proximal dendrite GO:1990635 IDA