Gene description for Rab12
Gene name RAB12, member RAS oncogene family
Gene symbol Rab12
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Rab12
ExoCarta ExoCarta_25530
Vesiclepedia VP_25530
Entrez Gene 25530
UniProt P35284  
 Rab12 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Rab12
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IEA
    GTP binding GO:0005525 IEA
    GTP binding GO:0005525 TAS
    GDP binding GO:0019003 ISO
    GDP binding GO:0019003 ISS
Biological Process
    exocytosis GO:0006887 IBA
    autophagy GO:0006914 IEA
    endosome to lysosome transport GO:0008333 ISO
    endosome to lysosome transport GO:0008333 ISS
    protein transport GO:0015031 IEA
    positive regulation of macroautophagy GO:0016239 ISO
    protein catabolic process GO:0030163 ISO
    protein catabolic process GO:0030163 ISS
    endocytic recycling GO:0032456 IBA
    Rab protein signal transduction GO:0032482 IEA
    cellular response to type II interferon GO:0071346 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    lysosome GO:0005764 ISO
    lysosome GO:0005764 ISS
    lysosomal membrane GO:0005765 IEA
    endosome GO:0005768 IBA
    autophagosome GO:0005776 ISO
    plasma membrane GO:0005886 IBA
    synaptic vesicle GO:0008021 IBA
    membrane GO:0016020 IEA
    trans-Golgi network transport vesicle GO:0030140 IBA
    secretory granule GO:0030141 IDA
    phagocytic vesicle GO:0045335 ISO
    recycling endosome membrane GO:0055038 ISO
    recycling endosome membrane GO:0055038 ISS
 Experiment description of studies that identified Rab12 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Rab12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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