Gene description for Ctse
Gene name cathepsin E
Gene symbol Ctse
Other names/aliases CEA
CEB
Ctsea
Species Rattus norvegicus
 Database cross references - Ctse
ExoCarta ExoCarta_25424
Vesiclepedia VP_25424
Entrez Gene 25424
UniProt P16228  
 Ctse identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ctse
Molecular Function
    aspartic-type endopeptidase activity GO:0004190 IBA
    aspartic-type endopeptidase activity GO:0004190 IDA
    aspartic-type endopeptidase activity GO:0004190 ISO
    peptidase activity GO:0008233 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    proteolysis GO:0006508 IBA
    proteolysis GO:0006508 ISO
    protein autoprocessing GO:0016540 IMP
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IBA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IDA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 ISO
Subcellular Localization
    endosome GO:0005768 IBA
    endosome GO:0005768 IDA
    endosome GO:0005768 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Ctse in sEVs
1
Experiment ID 97
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ctse
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ctse is involved
PathwayEvidenceSource
Adaptive Immune System IEA Reactome
Immune System IEA Reactome
MHC class II antigen presentation IEA Reactome





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