Gene description for Anxa1
Gene name	annexin A1
Gene symbol	Anxa1
Other names/aliases	Anx1 p35
Species	Rattus norvegicus
Database cross references - Anxa1
ExoCarta	ExoCarta_25380
Vesiclepedia	VP_25380
Entrez Gene	25380
UniProt	P07150
Anxa1 identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Anxa1

Molecular Function     phosphatidylserine binding GO:0001786 IBA     single-stranded DNA binding GO:0003697 IDA     single-stranded DNA binding GO:0003697 IDA     single-stranded RNA binding GO:0003727 IDA     calcium ion binding GO:0005509 IEA     calcium ion binding GO:0005509 ISO     calcium ion binding GO:0005509 ISS     phospholipid binding GO:0005543 IDA     calcium-dependent phospholipid binding GO:0005544 IBA     calcium-dependent phospholipid binding GO:0005544 IEA     calcium-dependent phospholipid binding GO:0005544 ISO     calcium-dependent phospholipid binding GO:0005544 ISS     calcium-dependent phospholipid binding GO:0005544 TAS     lipid binding GO:0008289 ISO     phospholipase A2 inhibitor activity GO:0019834 IDA     phospholipase A2 inhibitor activity GO:0019834 IEA     phospholipase A2 inhibitor activity GO:0019834 ISO     double-stranded DNA helicase activity GO:0036121 IDA     identical protein binding GO:0042802 IPI     calcium-dependent protein binding GO:0048306 IEA     calcium-dependent protein binding GO:0048306 ISO     DNA/DNA annealing activity GO:1990814 IDA Biological Process     neutrophil homeostasis GO:0001780 ISO     adaptive immune response GO:0002250 IEA     monocyte chemotaxis GO:0002548 IEA     monocyte chemotaxis GO:0002548 ISO     monocyte chemotaxis GO:0002548 ISS     regulation of leukocyte migration GO:0002685 IEA     regulation of leukocyte migration GO:0002685 ISO     regulation of leukocyte migration GO:0002685 ISS     phagocytosis GO:0006909 IBA     phagocytosis GO:0006909 ISO     phagocytosis GO:0006909 ISS     inflammatory response GO:0006954 IEA     inflammatory response GO:0006954 ISO     inflammatory response GO:0006954 ISS     signal transduction GO:0007165 IBA     signal transduction GO:0007165 ISO     cell surface receptor signaling pathway GO:0007166 IDA     G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 IEA     G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 ISO     G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 ISS     regulation of cell shape GO:0008360 IEA     regulation of cell shape GO:0008360 ISO     regulation of cell shape GO:0008360 ISS     response to xenobiotic stimulus GO:0009410 IEP     response to hormone GO:0009725 IEP     response to X-ray GO:0010165 IEP     response to organic cyclic compound GO:0014070 IEP     myoblast migration involved in skeletal muscle regeneration GO:0014839 IEA     myoblast migration involved in skeletal muscle regeneration GO:0014839 ISO     peptide cross-linking GO:0018149 ISO     actin cytoskeleton organization GO:0030036 IEA     actin cytoskeleton organization GO:0030036 ISO     actin cytoskeleton organization GO:0030036 ISS     insulin secretion GO:0030073 IDA     keratinocyte differentiation GO:0030216 IEA     keratinocyte differentiation GO:0030216 ISO     prostate gland development GO:0030850 IEP     endocrine pancreas development GO:0031018 IEP     positive regulation of vesicle fusion GO:0031340 IEA     positive regulation of vesicle fusion GO:0031340 ISO     positive regulation of prostaglandin biosynthetic process GO:0031394 IMP     response to estradiol GO:0032355 IEP     DNA duplex unwinding GO:0032508 IDA     regulation of interleukin-1 production GO:0032652 IEA     regulation of interleukin-1 production GO:0032652 ISO     regulation of interleukin-1 production GO:0032652 ISS     negative regulation of interleukin-8 production GO:0032717 IEA     negative regulation of interleukin-8 production GO:0032717 ISO     positive regulation of interleukin-2 production GO:0032743 IEA     positive regulation of interleukin-2 production GO:0032743 ISO     positive regulation of interleukin-2 production GO:0032743 ISS     positive regulation of neutrophil apoptotic process GO:0033031 IEA     positive regulation of neutrophil apoptotic process GO:0033031 ISO     cellular response to vascular endothelial growth factor stimulus GO:0035924 IEA     cellular response to vascular endothelial growth factor stimulus GO:0035924 ISO     gliogenesis GO:0042063 IEP     positive regulation of T cell proliferation GO:0042102 IEA     positive regulation of T cell proliferation GO:0042102 ISO     positive regulation of T cell proliferation GO:0042102 ISS     neutrophil activation GO:0042119 IEA     neutrophil activation GO:0042119 ISO     neutrophil activation GO:0042119 ISS     regulation of cell population proliferation GO:0042127 ISO     positive regulation of apoptotic process GO:0043065 IMP     response to peptide hormone GO:0043434 IEP     estrous cycle GO:0044849 IEP     innate immune response GO:0045087 IEA     positive regulation of T-helper 1 cell differentiation GO:0045627 IEA     positive regulation of T-helper 1 cell differentiation GO:0045627 ISO     positive regulation of T-helper 1 cell differentiation GO:0045627 ISS     negative regulation of T-helper 2 cell differentiation GO:0045629 IEA     negative regulation of T-helper 2 cell differentiation GO:0045629 ISO     negative regulation of T-helper 2 cell differentiation GO:0045629 ISS     negative regulation of exocytosis GO:0045920 IEA     negative regulation of exocytosis GO:0045920 ISO     negative regulation of exocytosis GO:0045920 ISS     alpha-beta T cell differentiation GO:0046632 IEA     alpha-beta T cell differentiation GO:0046632 ISO     regulation of hormone secretion GO:0046883 IEA     regulation of hormone secretion GO:0046883 ISO     regulation of hormone secretion GO:0046883 ISS     arachidonate secretion GO:0050482 IEA     arachidonate secretion GO:0050482 ISO     negative regulation of protein secretion GO:0050709 IMP     regulation of inflammatory response GO:0050727 IEA     regulation of inflammatory response GO:0050727 ISO     regulation of inflammatory response GO:0050727 ISS     response to glucocorticoid GO:0051384 IEP     cellular response to hydrogen peroxide GO:0070301 IMP     hepatocyte differentiation GO:0070365 IEP     prolactin secretion GO:0070459 IMP     response to interleukin-1 GO:0070555 IEP     cellular response to glucocorticoid stimulus GO:0071385 IBA     cellular response to glucocorticoid stimulus GO:0071385 IDA     cellular response to glucocorticoid stimulus GO:0071385 IEA     cellular response to glucocorticoid stimulus GO:0071385 ISO     granulocyte chemotaxis GO:0071621 IEA     granulocyte chemotaxis GO:0071621 ISO     granulocyte chemotaxis GO:0071621 ISS     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 IEA     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISO     positive regulation of wound healing GO:0090303 IEA     positive regulation of wound healing GO:0090303 ISO     positive regulation of wound healing GO:0090303 ISS     neutrophil clearance GO:0097350 IEA     neutrophil clearance GO:0097350 ISO     positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA     positive regulation of G1/S transition of mitotic cell cycle GO:1900087 ISO     negative regulation of phospholipase A2 activity GO:1900138 IDA Subcellular Localization     cornified envelope GO:0001533 IEA     cornified envelope GO:0001533 ISO     cornified envelope GO:0001533 ISO     phagocytic cup GO:0001891 IEA     extracellular region GO:0005576 IEA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 IEA     nucleus GO:0005634 ISO     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     endosome GO:0005768 ISO     early endosome GO:0005769 IEA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     actin filament GO:0005884 IEA     actin filament GO:0005884 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 ISO     cilium GO:0005929 IEA     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     endosome membrane GO:0010008 IEA     vesicle membrane GO:0012506 IBA     basolateral plasma membrane GO:0016323 IEA     apical plasma membrane GO:0016324 IEA     apical plasma membrane GO:0016324 ISO     apical plasma membrane GO:0016324 ISS     lateral plasma membrane GO:0016328 IEA     lateral plasma membrane GO:0016328 ISO     lateral plasma membrane GO:0016328 ISS     motile cilium GO:0031514 IEA     motile cilium GO:0031514 ISO     motile cilium GO:0031514 ISS     early endosome membrane GO:0031901 ISO     early endosome membrane GO:0031901 ISS     mitochondrial membrane GO:0031966 IDA     protein-containing complex GO:0032991 IDA     sarcolemma GO:0042383 IEA     sarcolemma GO:0042383 ISO     mast cell granule GO:0042629 IDA     extracellular exosome GO:0070062 IEA     extracellular exosome GO:0070062 ISO     extracellular exosome GO:0070062 ISS     synaptic membrane GO:0097060 IDA