Gene description for Acadvl
Gene name acyl-CoA dehydrogenase, very long chain
Gene symbol Acadvl
Other names/aliases VLCAD
Species Rattus norvegicus
 Database cross references - Acadvl
ExoCarta ExoCarta_25363
Vesiclepedia VP_25363
Entrez Gene 25363
UniProt P45953  
 Acadvl identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
Reticulocytes 21828046    
 Gene ontology annotations for Acadvl
Molecular Function
    fatty-acyl-CoA binding GO:0000062 IBA
    fatty-acyl-CoA binding GO:0000062 IDA
    acyl-CoA dehydrogenase activity GO:0003995 IDA
    acyl-CoA dehydrogenase activity GO:0003995 ISO
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 IDA
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 IEA
    long-chain fatty acyl-CoA dehydrogenase activity GO:0004466 ISO
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 IBA
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 IDA
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 IEA
    very-long-chain fatty acyl-CoA dehydrogenase activity GO:0017099 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
    flavin adenine dinucleotide binding GO:0050660 IDA
    flavin adenine dinucleotide binding GO:0050660 IEA
    flavin adenine dinucleotide binding GO:0050660 ISO
Biological Process
    temperature homeostasis GO:0001659 IEA
    temperature homeostasis GO:0001659 ISO
    fatty acid beta-oxidation GO:0006635 IDA
    fatty acid catabolic process GO:0009062 ISO
    response to cold GO:0009409 IEA
    response to cold GO:0009409 ISO
    epithelial cell differentiation GO:0030855 IEA
    epithelial cell differentiation GO:0030855 ISO
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IEA
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 ISO
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 ISS
    negative regulation of fatty acid biosynthetic process GO:0045717 IEA
    negative regulation of fatty acid biosynthetic process GO:0045717 ISO
    negative regulation of fatty acid oxidation GO:0046322 IEA
    negative regulation of fatty acid oxidation GO:0046322 ISO
    regulation of cholesterol metabolic process GO:0090181 IEA
    regulation of cholesterol metabolic process GO:0090181 ISO
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    mitochondrion GO:0005739 ISO
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 IEA
    mitochondrial membrane GO:0031966 ISO
    mitochondrial nucleoid GO:0042645 IEA
    mitochondrial nucleoid GO:0042645 ISO
 Experiment description of studies that identified Acadvl in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 97
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Acadvl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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