Gene description for Hk1
Gene name	hexokinase 1
Gene symbol	Hk1
Other names/aliases	HEXOKIN
Species	Rattus norvegicus
Database cross references - Hk1
ExoCarta	ExoCarta_25058
Vesiclepedia	VP_25058
Entrez Gene	25058
UniProt	P05708
Hk1 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Hk1

Molecular Function     glucokinase activity GO:0004340 IBA     glucokinase activity GO:0004340 IDA     glucokinase activity GO:0004340 IEA     glucokinase activity GO:0004340 ISO     hexokinase activity GO:0004396 IDA     hexokinase activity GO:0004396 IEA     hexokinase activity GO:0004396 ISO     protein kinase activity GO:0004672 IDA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IC     ATP binding GO:0005524 IDA     ATP binding GO:0005524 IEA     D-glucose binding GO:0005536 IDA     D-glucose binding GO:0005536 IEA     fructokinase activity GO:0008865 IBA     fructokinase activity GO:0008865 IDA     ATP hydrolysis activity GO:0016887 IC     mannokinase activity GO:0019158 IBA     mannokinase activity GO:0019158 IDA     mannokinase activity GO:0019158 ISO     identical protein binding GO:0042802 IPI     peptidoglycan binding GO:0042834 IEA     peptidoglycan binding GO:0042834 ISO     protein-containing complex binding GO:0044877 IDA     glucosamine kinase activity GO:0047931 IEA Biological Process     response to hypoxia GO:0001666 IEP     intracellular glucose homeostasis GO:0001678 IBA     intracellular glucose homeostasis GO:0001678 IEA     positive regulation of cytokine production involved in immune response GO:0002720 IEA     positive regulation of cytokine production involved in immune response GO:0002720 ISO     response to ischemia GO:0002931 IDA     fructose 6-phosphate metabolic process GO:0006002 IDA     glucose metabolic process GO:0006006 IBA     mannose metabolic process GO:0006013 IDA     glycolytic process GO:0006096 IBA     glycolytic process GO:0006096 IDA     glycolytic process GO:0006096 IEA     protein phosphorylation GO:0006468 IDA     inflammatory response GO:0006954 IEA     response to brassinosteroid GO:0009741 IEP     regulation of anion channel activity GO:0010359 IDA     peptidyl-serine phosphorylation GO:0018105 IDA     peptidyl-threonine phosphorylation GO:0018107 IDA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     hexose metabolic process GO:0019318 IEA     positive regulation of interleukin-1 beta production GO:0032731 IEA     positive regulation of interleukin-1 beta production GO:0032731 ISO     negative regulation of apoptotic process GO:0043066 IMP     innate immune response GO:0045087 IEA     protein autophosphorylation GO:0046777 IDA     carbohydrate phosphorylation GO:0046835 IDA     carbohydrate phosphorylation GO:0046835 IEA     carbohydrate phosphorylation GO:0046835 ISO     glucose 6-phosphate metabolic process GO:0051156 IBA     glucose 6-phosphate metabolic process GO:0051156 IDA     glucose 6-phosphate metabolic process GO:0051156 IEA     canonical glycolysis GO:0061621 IEA     canonical glycolysis GO:0061621 ISO     GDP-mannose biosynthetic process from mannose GO:0061728 IEA     GDP-mannose biosynthetic process from mannose GO:0061728 ISO     establishment of protein localization to mitochondrion GO:0072655 IEA     establishment of protein localization to mitochondrion GO:0072655 ISO     maintenance of protein location in mitochondrion GO:0072656 IEA     maintenance of protein location in mitochondrion GO:0072656 ISO     GDP-mannose biosynthetic process from glucose GO:0141199 IEA     GDP-mannose biosynthetic process from glucose GO:0141199 ISO     response to ketamine GO:1901986 IEP Subcellular Localization     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IDA     mitochondrion GO:0005739 ISO     mitochondrial outer membrane GO:0005741 IEA     cytosol GO:0005829 IBA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISO     caveola GO:0005901 IDA     protein-containing complex GO:0032991 IDA     membrane raft GO:0045121 IEA     membrane raft GO:0045121 ISO