Gene description for Cyp2d2
Gene name cytochrome P450, family 2, subfamily d, polypeptide 2
Gene symbol Cyp2d2
Other names/aliases Cyp2d26
Species Rattus norvegicus
 Database cross references - Cyp2d2
ExoCarta ExoCarta_25053
Vesiclepedia VP_25053
Entrez Gene 25053
UniProt P10634  
 Cyp2d2 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Cyp2d2
Molecular Function
    monooxygenase activity GO:0004497 IDA
    monooxygenase activity GO:0004497 IEA
    monooxygenase activity GO:0004497 TAS
    iron ion binding GO:0005506 IEA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 IEA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IBA
    heme binding GO:0020037 IBA
    heme binding GO:0020037 IEA
Biological Process
    xenobiotic metabolic process GO:0006805 IBA
    female pregnancy GO:0007565 IEP
    response to xenobiotic stimulus GO:0009410 IDA
    arachidonate metabolic process GO:0019369 IBA
    response to genistein GO:0033595 IEP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified Cyp2d2 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cyp2d2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cyp2d2 is involved
No pathways found





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