Gene description for Cth
Gene name	cystathionine gamma-lyase
Gene symbol	Cth
Other names/aliases	H
Species	Rattus norvegicus
Database cross references - Cth
ExoCarta	ExoCarta_24962
Vesiclepedia	VP_24962
Entrez Gene	24962
UniProt	P18757
Cth identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702
Urine	20535238

Gene ontology annotations for Cth

Molecular Function     cystathionine gamma-lyase activity GO:0004123 IBA     cystathionine gamma-lyase activity GO:0004123 IEA     cystathionine gamma-lyase activity GO:0004123 ISO     cystathionine gamma-lyase activity GO:0004123 ISS     calmodulin binding GO:0005516 IEA     pyridoxal phosphate binding GO:0030170 IBA     pyridoxal phosphate binding GO:0030170 IEA     pyridoxal phosphate binding GO:0030170 ISO     pyridoxal phosphate binding GO:0030170 ISS     pyridoxal phosphate binding GO:0030170 TAS     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     L-cystine L-cysteine-lyase (deaminating) GO:0044540 IEA     L-cystine L-cysteine-lyase (deaminating) GO:0044540 ISO     L-cystine L-cysteine-lyase (deaminating) GO:0044540 ISS     homocysteine desulfhydrase activity GO:0047982 IEA     L-cysteine desulfhydrase activity GO:0080146 IEA     selenocystathionine gamma-lyase activity GO:0098606 IEA Biological Process     lipid metabolic process GO:0006629 IEA     glutathione metabolic process GO:0006749 IMP     negative regulation of cell population proliferation GO:0008285 IMP     protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine GO:0018272 ISO     protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine GO:0018272 ISS     cysteine biosynthetic process via cystathionine GO:0019343 IBA     cysteine biosynthetic process via cystathionine GO:0019343 IEA     cysteine biosynthetic process via cystathionine GO:0019343 ISO     cysteine biosynthetic process GO:0019344 IEA     cysteine biosynthetic process GO:0019344 ISO     cysteine biosynthetic process GO:0019344 ISS     transsulfuration GO:0019346 IBA     transsulfuration GO:0019346 IEA     transsulfuration GO:0019346 ISO     transsulfuration GO:0019346 TAS     negative regulation of cell growth GO:0030308 IMP     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISS     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISS     protein sulfhydration GO:0044524 ISO     protein sulfhydration GO:0044524 ISS     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS     protein homotetramerization GO:0051289 IEA     protein homotetramerization GO:0051289 ISO     hydrogen sulfide biosynthetic process GO:0070814 IEA     hydrogen sulfide biosynthetic process GO:0070814 ISO     hydrogen sulfide biosynthetic process GO:0070814 ISS     positive regulation of aortic smooth muscle cell differentiation GO:1904831 IEA     positive regulation of aortic smooth muscle cell differentiation GO:1904831 ISO     cellular response to leukemia inhibitory factor GO:1990830 IEA     cellular response to leukemia inhibitory factor GO:1990830 ISO     negative regulation of apoptotic signaling pathway GO:2001234 IEA     negative regulation of apoptotic signaling pathway GO:2001234 ISO Subcellular Localization     cytoplasm GO:0005737 IBA     cytosol GO:0005829 TAS