Gene description for Cyp2a2
Gene name cytochrome P450, family 2, subfamily a, polypeptide 2
Gene symbol Cyp2a2
Other names/aliases CYP2A21
RATCYP2A21
Species Rattus norvegicus
 Database cross references - Cyp2a2
ExoCarta ExoCarta_24895
Vesiclepedia VP_24895
Entrez Gene 24895
UniProt P15149  
 Cyp2a2 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Cyp2a2
Molecular Function
    iron ion binding GO:0005506 IEA
    arachidonate epoxygenase activity GO:0008392 IBA
    steroid hydroxylase activity GO:0008395 IDA
    steroid hydroxylase activity GO:0008395 TAS
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IBA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IEA
    heme binding GO:0020037 IBA
    heme binding GO:0020037 IEA
Biological Process
    xenobiotic metabolic process GO:0006805 IBA
    coumarin metabolic process GO:0009804 IBA
    epoxygenase P450 pathway GO:0019373 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    endoplasmic reticulum membrane GO:0005789 IEA
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified Cyp2a2 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cyp2a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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