Gene description for Sdc4
Gene name syndecan 4
Gene symbol Sdc4
Other names/aliases RATRYUDOCA
RYUDOCA
Species Rattus norvegicus
 Database cross references - Sdc4
ExoCarta ExoCarta_24771
Vesiclepedia VP_24771
Entrez Gene 24771
UniProt P34901  
 Sdc4 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Sdc4
Molecular Function
    fibronectin binding GO:0001968 IDA
    protein kinase C binding GO:0005080 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    thrombospondin receptor activity GO:0070053 ISO
Biological Process
    ureteric bud development GO:0001657 IEP
    neural tube closure GO:0001843 ISO
    cell adhesion GO:0007155 NAS
    cell-cell signaling GO:0007267 NAS
    regulation of fibroblast migration GO:0010762 ISO
    cell migration GO:0016477 IBA
    wound healing GO:0042060 ISO
    negative regulation of T cell proliferation GO:0042130 ISO
    positive regulation of protein kinase activity GO:0045860 IMP
    positive regulation of stress fiber assembly GO:0051496 IMP
    positive regulation of focal adhesion assembly GO:0051894 IMP
    inner ear receptor cell stereocilium organization GO:0060122 ISO
    positive regulation of exosomal secretion GO:1903543 ISO
    positive regulation of extracellular exosome assembly GO:1903553 ISO
    regulation of aortic smooth muscle cell differentiation GO:1904829 IDA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 IDA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    costamere GO:0043034 IDA
 Experiment description of studies that identified Sdc4 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Sdc4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here