Gene description for Reln
Gene name reelin
Gene symbol Reln
Other names/aliases Reelen
Rl
reeler
Species Rattus norvegicus
 Database cross references - Reln
ExoCarta ExoCarta_24718
Entrez Gene 24718
UniProt P58751  
 Reln identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Reln
Molecular Function
    serine-type peptidase activity GO:0008236 IEA
    metal ion binding GO:0046872 IEA
    molecular_function GO:0003674 ND
    lipoprotein particle receptor binding GO:0070325 ISO
    very-low-density lipoprotein particle receptor binding GO:0070326 ISO
    protein serine/threonine/tyrosine kinase activity GO:0004712 ISS
Biological Process
    positive regulation of CREB transcription factor activity GO:0032793 ISO
    regulation of synaptic transmission GO:0050804 ISO
    spinal cord patterning GO:0021511 ISS
    response to progesterone GO:0032570 IEP
    hippocampus development GO:0021766 ISO
    response to hormone GO:0009725 IEP
    memory GO:0007613 IEP
    associative learning GO:0008306 ISO
    neuron migration GO:0001764 ISS
    orbitofrontal cortex development GO:0021769 IEP
    central nervous system development GO:0007417 ISS
    response to organic cyclic compound GO:0014070 IEP
    reelin-mediated signaling pathway GO:0038026 ISO
    response to mechanical stimulus GO:0009612 IEP
    response to amino acid GO:0043200 IEP
    N-methyl-D-aspartate receptor clustering GO:0097114 ISO
    locomotory behavior GO:0007626 ISO
    response to drug GO:0042493 IEP
    proteolysis GO:0006508 IEA
    response to fatty acid GO:0070542 IEP
    positive regulation of protein tyrosine kinase activity GO:0061098 ISO
    response to ethanol GO:0045471 IEP
    long-term memory GO:0007616 ISO
    regulation of behavior GO:0050795 ISO
    cerebral cortex tangential migration GO:0021800 ISS
    cell adhesion GO:0007155 IEA
    midgut development GO:0007494 IEP
    thyroid hormone metabolic process GO:0042403 ISO
    dentate gyrus development GO:0021542 IMP
    cell migration GO:0016477 ISO
    positive regulation of TOR signaling GO:0032008 ISO
    receptor localization to synapse GO:0097120 ISO
    cerebral cortex development GO:0021987 ISO
    response to corticosterone GO:0051412 IEP
    positive regulation of long-term synaptic potentiation GO:1900273 ISO
    postsynaptic density protein 95 clustering GO:0097119 ISO
    social behavior GO:0035176 IEP
    cellular response to dexamethasone stimulus GO:0071549 IEP
    ventral spinal cord development GO:0021517 IEA
    regulation of gene expression GO:0010468 ISO
    brain development GO:0007420 ISS
    positive regulation of dendritic spine morphogenesis GO:0061003 ISO
    peptidyl-tyrosine phosphorylation GO:0018108 ISS
    glial cell differentiation GO:0010001 ISS
    response to lithium ion GO:0010226 IEP
    response to axon injury GO:0048678 IEP
    positive regulation of synaptic transmission, glutamatergic GO:0051968 ISO
    axon guidance GO:0007411 ISS
    response to toxic substance GO:0009636 IEP
    response to pain GO:0048265 ISS
    dendrite development GO:0016358 ISO
    positive regulation of small GTPase mediated signal transduction GO:0051057 ISS
    response to electrical stimulus GO:0051602 IEP
    response to insecticide GO:0017085 IEP
    positive regulation of neuron projection development GO:0010976 ISO
    protein localization to synapse GO:0035418 ISO
    positive regulation of lateral motor column neuron migration GO:1902078 ISO
    positive regulation of excitatory postsynaptic membrane potential GO:2000463 ISO
    positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity GO:2000969 ISO
    hypothalamus development GO:0021854 IEP
    forebrain development GO:0030900 ISO
    lateral motor column neuron migration GO:0097477 ISO
    layer formation in cerebral cortex GO:0021819 ISO
    cell morphogenesis involved in differentiation GO:0000904 ISS
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISO
    regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000310 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    positive regulation of synapse maturation GO:0090129 ISO
    positive regulation of protein kinase activity GO:0045860 ISS
Subcellular Localization
    neuron projection GO:0043005 IDA
    neuronal cell body GO:0043025 IDA
    axon GO:0030424 IDA
    perikaryon GO:0043204 IDA
    dendrite GO:0030425 ISS
    cytoplasm GO:0005737 ISS
    extracellular space GO:0005615 ISS
    proteinaceous extracellular matrix GO:0005578 ISO
 Experiment description of studies that identified Reln in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Reln
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Reln is involved
No pathways found





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