Gene description for Reln
Gene name	reelin
Gene symbol	Reln
Other names/aliases	Reelen Rl reeler
Species	Rattus norvegicus
Database cross references - Reln
ExoCarta	ExoCarta_24718
Vesiclepedia	VP_24718
Entrez Gene	24718
UniProt	P58751
Reln identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Reln

Molecular Function     serine-type peptidase activity GO:0008236 IEA     serine-type peptidase activity GO:0008236 ISO     serine-type peptidase activity GO:0008236 ISS     metal ion binding GO:0046872 IEA     receptor ligand activity GO:0048018 IEA     receptor ligand activity GO:0048018 ISO     lipoprotein particle receptor binding GO:0070325 IBA     lipoprotein particle receptor binding GO:0070325 IEA     lipoprotein particle receptor binding GO:0070325 ISO     very-low-density lipoprotein particle receptor binding GO:0070326 IEA     very-low-density lipoprotein particle receptor binding GO:0070326 ISO Biological Process     cell morphogenesis GO:0000902 ISO     cell morphogenesis GO:0000902 ISS     neuron migration GO:0001764 IBA     neuron migration GO:0001764 IEA     neuron migration GO:0001764 IMP     neuron migration GO:0001764 ISO     neuron migration GO:0001764 ISS     proteolysis GO:0006508 IEA     cell adhesion GO:0007155 IEA     axon guidance GO:0007411 IEA     axon guidance GO:0007411 ISO     axon guidance GO:0007411 ISS     central nervous system development GO:0007417 IBA     central nervous system development GO:0007417 IEA     central nervous system development GO:0007417 ISO     central nervous system development GO:0007417 ISS     brain development GO:0007420 ISO     brain development GO:0007420 ISS     midgut development GO:0007494 IEP     learning GO:0007612 ISO     memory GO:0007613 IEP     long-term memory GO:0007616 IEA     long-term memory GO:0007616 ISO     locomotory behavior GO:0007626 IEA     locomotory behavior GO:0007626 IMP     locomotory behavior GO:0007626 ISO     associative learning GO:0008306 IEA     associative learning GO:0008306 ISO     response to xenobiotic stimulus GO:0009410 IEP     response to mechanical stimulus GO:0009612 IEP     response to toxic substance GO:0009636 IEP     response to hormone GO:0009725 IEP     glial cell differentiation GO:0010001 IEA     glial cell differentiation GO:0010001 ISO     glial cell differentiation GO:0010001 ISS     regulation of gene expression GO:0010468 IEA     regulation of gene expression GO:0010468 ISO     positive regulation of neuron projection development GO:0010976 ISO     response to organic cyclic compound GO:0014070 IEP     synaptic vesicle exocytosis GO:0016079 EXP     synaptic vesicle exocytosis GO:0016079 IDA     synaptic vesicle exocytosis GO:0016079 IMP     dendrite development GO:0016358 IEA     dendrite development GO:0016358 ISO     cell migration GO:0016477 ISO     response to insecticide GO:0017085 IEP     peptidyl-tyrosine phosphorylation GO:0018108 ISO     peptidyl-tyrosine phosphorylation GO:0018108 ISS     spinal cord patterning GO:0021511 IEA     spinal cord patterning GO:0021511 IEP     spinal cord patterning GO:0021511 ISO     spinal cord patterning GO:0021511 ISS     ventral spinal cord development GO:0021517 IEA     ventral spinal cord development GO:0021517 ISO     dentate gyrus development GO:0021542 IMP     hippocampus development GO:0021766 IEA     hippocampus development GO:0021766 ISO     orbitofrontal cortex development GO:0021769 IEP     cerebral cortex tangential migration GO:0021800 IEA     cerebral cortex tangential migration GO:0021800 ISO     cerebral cortex tangential migration GO:0021800 ISS     layer formation in cerebral cortex GO:0021819 IEA     layer formation in cerebral cortex GO:0021819 ISO     layer formation in cerebral cortex GO:0021819 ISO     layer formation in cerebral cortex GO:0021819 ISS     hypothalamus development GO:0021854 IEP     cerebral cortex development GO:0021987 IEP     cerebral cortex development GO:0021987 ISO     forebrain development GO:0030900 ISO     positive regulation of TOR signaling GO:0032008 IEA     positive regulation of TOR signaling GO:0032008 ISO     response to progesterone GO:0032570 IEP     positive regulation of CREB transcription factor activity GO:0032793 ISO     social behavior GO:0035176 IEP     protein localization to synapse GO:0035418 IEA     protein localization to synapse GO:0035418 ISO     reelin-mediated signaling pathway GO:0038026 IEA     reelin-mediated signaling pathway GO:0038026 ISO     reelin-mediated signaling pathway GO:0038026 ISS     thyroid hormone metabolic process GO:0042403 ISO     response to amino acid GO:0043200 IEP     response to ethanol GO:0045471 IEP     positive regulation of protein kinase activity GO:0045860 ISO     positive regulation of protein kinase activity GO:0045860 ISS     response to pain GO:0048265 IEA     response to pain GO:0048265 ISO     response to pain GO:0048265 ISS     response to axon injury GO:0048678 IEP     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     regulation of behavior GO:0050795 IEA     regulation of behavior GO:0050795 ISO     modulation of chemical synaptic transmission GO:0050804 ISO     positive regulation of small GTPase mediated signal transduction GO:0051057 IEA     positive regulation of small GTPase mediated signal transduction GO:0051057 ISO     positive regulation of small GTPase mediated signal transduction GO:0051057 ISS     response to corticosterone GO:0051412 IEP     response to electrical stimulus GO:0051602 IEP     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISO     long-term synaptic potentiation GO:0060291 IEA     long-term synaptic potentiation GO:0060291 ISO     positive regulation of dendritic spine morphogenesis GO:0061003 IEA     positive regulation of dendritic spine morphogenesis GO:0061003 ISO     positive regulation of protein tyrosine kinase activity GO:0061098 ISO     response to fatty acid GO:0070542 IEP     cellular response to dexamethasone stimulus GO:0071549 IEP     regulation of synapse maturation GO:0090128 ISO     positive regulation of synapse maturation GO:0090129 IEA     positive regulation of synapse maturation GO:0090129 ISO     postsynaptic density assembly GO:0097107 IEA     postsynaptic density assembly GO:0097107 ISO     NMDA glutamate receptor clustering GO:0097114 IEA     NMDA glutamate receptor clustering GO:0097114 ISO     postsynaptic density protein 95 clustering GO:0097119 IEA     postsynaptic density protein 95 clustering GO:0097119 ISO     receptor localization to synapse GO:0097120 IEA     receptor localization to synapse GO:0097120 ISO     motor neuron migration GO:0097475 ISO     lateral motor column neuron migration GO:0097477 IEA     lateral motor column neuron migration GO:0097477 ISO     positive regulation of long-term synaptic potentiation GO:1900273 IEA     positive regulation of long-term synaptic potentiation GO:1900273 ISO     positive regulation of lateral motor column neuron migration GO:1902078 IEA     positive regulation of lateral motor column neuron migration GO:1902078 ISO     interneuron migration GO:1904936 IEA     interneuron migration GO:1904936 ISO     regulation of NMDA receptor activity GO:2000310 ISO     positive regulation of excitatory postsynaptic potential GO:2000463 IEA     positive regulation of excitatory postsynaptic potential GO:2000463 ISO     positive regulation of AMPA receptor activity GO:2000969 ISO Subcellular Localization     extracellular region GO:0005576 IEA     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     extracellular space GO:0005615 ISO     extracellular space GO:0005615 ISS     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     plasma membrane GO:0005886 IEA     axon GO:0030424 IDA     dendrite GO:0030425 IDA     dendrite GO:0030425 IEA     dendrite GO:0030425 ISO     dendrite GO:0030425 ISS     extracellular matrix GO:0031012 IEA     extracellular matrix GO:0031012 ISO     neuron projection GO:0043005 IBA     neuronal cell body GO:0043025 IDA     perikaryon GO:0043204 IDA     presynapse GO:0098793 IEA     reelin complex GO:0110157 IEA     reelin complex GO:0110157 ISO