Gene description for Slc15a4
Gene name solute carrier family 15 (oligopeptide transporter), member 4
Gene symbol Slc15a4
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Slc15a4
ExoCarta ExoCarta_246280
Vesiclepedia VP_246280
Entrez Gene 246280
UniProt O09014  
 Slc15a4 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Slc15a4
Molecular Function
    L-histidine transmembrane transporter activity GO:0005290 IBA
    L-histidine transmembrane transporter activity GO:0005290 IEA
    L-histidine transmembrane transporter activity GO:0005290 IMP
    L-histidine transmembrane transporter activity GO:0005290 ISO
    L-histidine transmembrane transporter activity GO:0005290 ISS
    peptide:proton symporter activity GO:0015333 IEA
    peptide:proton symporter activity GO:0015333 ISO
    peptide:proton symporter activity GO:0015333 ISS
    peptidoglycan transmembrane transporter activity GO:0015647 IEA
    peptidoglycan transmembrane transporter activity GO:0015647 ISO
    peptidoglycan transmembrane transporter activity GO:0015647 ISS
    dipeptide transmembrane transporter activity GO:0071916 IBA
    dipeptide transmembrane transporter activity GO:0071916 IEA
    dipeptide transmembrane transporter activity GO:0071916 ISO
    dipeptide transmembrane transporter activity GO:0071916 ISS
Biological Process
    protein transport GO:0015031 IEA
    histidine transport GO:0015817 IBA
    histidine transport GO:0015817 IMP
    peptidoglycan transport GO:0015835 IEA
    peptidoglycan transport GO:0015835 ISO
    peptidoglycan transport GO:0015835 ISS
    mast cell homeostasis GO:0033023 IEA
    mast cell homeostasis GO:0033023 ISO
    mast cell homeostasis GO:0033023 ISS
    positive regulation of toll-like receptor 7 signaling pathway GO:0034157 IEA
    positive regulation of toll-like receptor 7 signaling pathway GO:0034157 ISO
    positive regulation of toll-like receptor 7 signaling pathway GO:0034157 ISS
    positive regulation of toll-like receptor 8 signaling pathway GO:0034161 IEA
    positive regulation of toll-like receptor 8 signaling pathway GO:0034161 ISO
    positive regulation of toll-like receptor 8 signaling pathway GO:0034161 ISS
    positive regulation of toll-like receptor 9 signaling pathway GO:0034165 IEA
    positive regulation of toll-like receptor 9 signaling pathway GO:0034165 ISO
    positive regulation of toll-like receptor 9 signaling pathway GO:0034165 ISS
    innate immune response GO:0045087 IEA
    positive regulation of innate immune response GO:0045089 ISO
    positive regulation of innate immune response GO:0045089 ISS
    regulation of isotype switching to IgG isotypes GO:0048302 IEA
    regulation of isotype switching to IgG isotypes GO:0048302 ISO
    regulation of isotype switching to IgG isotypes GO:0048302 ISS
    regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0070424 ISO
    regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0070424 ISS
    positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070430 IEA
    positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070430 ISO
    positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070430 ISS
    positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070434 IEA
    positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070434 ISO
    positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070434 ISS
    L-histidine transmembrane export from vacuole GO:0089708 IEA
    L-histidine transmembrane export from vacuole GO:0089708 ISO
    dipeptide import across plasma membrane GO:0140206 IBA
    dipeptide import across plasma membrane GO:0140206 IEA
    dipeptide import across plasma membrane GO:0140206 ISO
    dipeptide import across plasma membrane GO:0140206 ISS
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    lysosomal membrane GO:0005765 ISO
    lysosomal membrane GO:0005765 ISS
    endosome membrane GO:0010008 ISO
    membrane GO:0016020 IBA
    early endosome membrane GO:0031901 IEA
    early endosome membrane GO:0031901 ISO
    endolysosome membrane GO:0036020 IEA
    endolysosome membrane GO:0036020 ISO
    endolysosome membrane GO:0036020 ISS
 Experiment description of studies that identified Slc15a4 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 96
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
4
Experiment ID 97
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc15a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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