Gene description for Mme
Gene name	membrane metallo-endopeptidase
Gene symbol	Mme
Other names/aliases	CD10 Nep SFE
Species	Rattus norvegicus
Database cross references - Mme
ExoCarta	ExoCarta_24590
Vesiclepedia	VP_24590
Entrez Gene	24590
UniProt	P07861
Mme identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041
Urine	20535238

Gene ontology annotations for Mme

Molecular Function     phosphatidylserine binding GO:0001786 IEA     phosphatidylserine binding GO:0001786 ISO     endopeptidase activity GO:0004175 ISO     metalloendopeptidase activity GO:0004222 IBA     metalloendopeptidase activity GO:0004222 IEA     metalloendopeptidase activity GO:0004222 ISO     metalloendopeptidase activity GO:0004222 ISS     peptidase activity GO:0008233 ISO     exopeptidase activity GO:0008238 IEA     exopeptidase activity GO:0008238 ISO     zinc ion binding GO:0008270 IEA     zinc ion binding GO:0008270 ISO     zinc ion binding GO:0008270 ISS     peptide binding GO:0042277 IDA     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     oligopeptidase activity GO:0070012 IDA     cardiolipin binding GO:1901612 IEA     cardiolipin binding GO:1901612 ISO Biological Process     kidney development GO:0001822 IEA     kidney development GO:0001822 IEP     kidney development GO:0001822 ISO     kidney development GO:0001822 ISS     placenta development GO:0001890 IEP     proteolysis GO:0006508 ISO     peptide metabolic process GO:0006518 IMP     learning or memory GO:0007611 IEA     learning or memory GO:0007611 ISO     substance P catabolic process GO:0010814 IEA     substance P catabolic process GO:0010814 ISO     substance P catabolic process GO:0010814 ISS     bradykinin catabolic process GO:0010815 IEA     bradykinin catabolic process GO:0010815 ISO     bradykinin catabolic process GO:0010815 ISS     protein processing GO:0016485 IBA     sensory perception of pain GO:0019233 IEA     sensory perception of pain GO:0019233 ISO     sensory perception of pain GO:0019233 ISS     protein catabolic process GO:0030163 IDA     lung development GO:0030324 IEP     hormone catabolic process GO:0042447 IEA     hormone catabolic process GO:0042447 ISO     hormone catabolic process GO:0042447 ISS     response to estrogen GO:0043627 IDA     creatinine metabolic process GO:0046449 IEA     creatinine metabolic process GO:0046449 ISO     creatinine metabolic process GO:0046449 ISS     amyloid-beta metabolic process GO:0050435 ISO     amyloid-beta metabolic process GO:0050435 ISS     positive regulation of neurogenesis GO:0050769 IEA     positive regulation of neurogenesis GO:0050769 ISO     neuropeptide processing GO:0061837 IEA     neuropeptide processing GO:0061837 ISO     cellular response to cytokine stimulus GO:0071345 IEA     cellular response to cytokine stimulus GO:0071345 ISO     cellular response to cytokine stimulus GO:0071345 ISS     cellular response to UV-A GO:0071492 IEA     cellular response to UV-A GO:0071492 ISO     cellular response to UV-A GO:0071492 ISS     cellular response to UV-B GO:0071493 IEA     cellular response to UV-B GO:0071493 ISO     cellular response to UV-B GO:0071493 ISS     replicative senescence GO:0090399 IEA     replicative senescence GO:0090399 ISO     replicative senescence GO:0090399 ISS     amyloid-beta clearance GO:0097242 IBA     amyloid-beta clearance GO:0097242 IDA     amyloid-beta clearance GO:0097242 ISO     amyloid-beta clearance by cellular catabolic process GO:0150094 IEA     amyloid-beta clearance by cellular catabolic process GO:0150094 IMP     amyloid-beta clearance by cellular catabolic process GO:0150094 ISO     positive regulation of long-term synaptic potentiation GO:1900273 IEA     positive regulation of long-term synaptic potentiation GO:1900273 ISO Subcellular Localization     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     early endosome GO:0005769 IEA     early endosome GO:0005769 ISO     trans-Golgi network GO:0005802 IEA     trans-Golgi network GO:0005802 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     brush border GO:0005903 IEA     brush border GO:0005903 ISO     brush border GO:0005903 ISS     synaptic vesicle GO:0008021 IEA     synaptic vesicle GO:0008021 ISO     synaptic vesicle GO:0008021 ISS     membrane GO:0016020 ISO     axon GO:0030424 IEA     axon GO:0030424 ISO     axon GO:0030424 ISS     dendrite GO:0030425 IEA     dendrite GO:0030425 ISO     dendrite GO:0030425 ISS     cytoplasmic vesicle GO:0031410 ISO     neuronal cell body GO:0043025 IEA     neuronal cell body GO:0043025 ISO     neuron projection terminus GO:0044306 IEA     neuron projection terminus GO:0044306 ISO     neuron projection terminus GO:0044306 ISS     membrane raft GO:0045121 IEA     membrane raft GO:0045121 ISO     synapse GO:0045202 ISO     synapse GO:0045202 ISS     presynapse GO:0098793 ISO