Gene description for Igf2
Gene name	insulin-like growth factor 2
Gene symbol	Igf2
Other names/aliases	IGFII RNIGF2
Species	Rattus norvegicus
Database cross references - Igf2
ExoCarta	ExoCarta_24483
Vesiclepedia	VP_24483
Entrez Gene	24483
UniProt	P01346
Igf2 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Igf2

Molecular Function     insulin receptor binding GO:0005158 ISO     insulin-like growth factor receptor binding GO:0005159 IBA     insulin-like growth factor receptor binding GO:0005159 ISO     integrin binding GO:0005178 ISO     integrin binding GO:0005178 ISS     hormone activity GO:0005179 IEA     protein binding GO:0005515 IPI     growth factor activity GO:0008083 IBA     growth factor activity GO:0008083 IEA     growth factor activity GO:0008083 ISO     transmembrane receptor protein tyrosine kinase activator activity GO:0030297 ISO     protein serine/threonine kinase activator activity GO:0043539 IBA     protein serine/threonine kinase activator activity GO:0043539 ISO     receptor ligand activity GO:0048018 ISO Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     negative regulation of transcription by RNA polymerase II GO:0000122 ISS     ossification GO:0001503 IEA     osteoblast differentiation GO:0001649 ISO     in utero embryonic development GO:0001701 ISO     embryonic placenta development GO:0001892 ISO     embryonic placenta development GO:0001892 ISS     glucose metabolic process GO:0006006 IEA     signal transduction GO:0007165 IEA     female pregnancy GO:0007565 IEP     memory GO:0007613 IMP     positive regulation of cell population proliferation GO:0008284 ISO     positive regulation of cell population proliferation GO:0008284 ISS     insulin receptor signaling pathway GO:0008286 ISO     response to xenobiotic stimulus GO:0009410 IDA     animal organ morphogenesis GO:0009887 ISO     response to organic cyclic compound GO:0014070 IDA     exocrine pancreas development GO:0031017 ISO     response to nutrient levels GO:0031667 IEP     response to estradiol GO:0032355 IEP     response to nicotine GO:0035094 IDA     response to nicotine GO:0035094 IEP     positive regulation of multicellular organism growth GO:0040018 ISO     positive regulation of activated T cell proliferation GO:0042104 IBA     positive regulation of activated T cell proliferation GO:0042104 ISO     positive regulation of MAPK cascade GO:0043410 IBA     positive regulation of MAPK cascade GO:0043410 ISO     positive regulation of blood vessel endothelial cell migration GO:0043536 IGI     response to ethanol GO:0045471 IEP     positive regulation of glycogen biosynthetic process GO:0045725 ISO     positive regulation of angiogenesis GO:0045766 IGI     positive regulation of mitotic nuclear division GO:0045840 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IBA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     negative regulation of natural killer cell mediated cytotoxicity GO:0045953 IDA     positive regulation of organ growth GO:0046622 ISO     positive regulation of insulin receptor signaling pathway GO:0046628 IBA     positive regulation of insulin receptor signaling pathway GO:0046628 ISO     insulin-like growth factor receptor signaling pathway GO:0048009 ISO     positive regulation of skeletal muscle tissue growth GO:0048633 ISO     striated muscle cell differentiation GO:0051146 ISO     regulation of muscle cell differentiation GO:0051147 IBA     regulation of muscle cell differentiation GO:0051147 ISO     regulation of muscle cell differentiation GO:0051147 ISS     negative regulation of muscle cell differentiation GO:0051148 ISO     negative regulation of muscle cell differentiation GO:0051148 ISS     positive regulation of cell division GO:0051781 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     embryonic placenta morphogenesis GO:0060669 ISO     spongiotrophoblast cell proliferation GO:0060720 ISO     cellular response to mechanical stimulus GO:0071260 IEP     positive regulation of steroid hormone biosynthetic process GO:0090031 IDA     positive regulation of vascular endothelial cell proliferation GO:1905564 IBA     positive regulation of vascular endothelial cell proliferation GO:1905564 IGI Subcellular Localization     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO