Gene description for Hmgcs2
Gene name 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Gene symbol Hmgcs2
Other names/aliases Hmgcs1
Mt3h3mg
Species Rattus norvegicus
 Database cross references - Hmgcs2
ExoCarta ExoCarta_24450
Vesiclepedia VP_24450
Entrez Gene 24450
 Hmgcs2 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Hmgcs2
Molecular Function
    hydroxymethylglutaryl-CoA synthase activity GO:0004421 IBA
    hydroxymethylglutaryl-CoA synthase activity GO:0004421 IDA
    hydroxymethylglutaryl-CoA synthase activity GO:0004421 ISO
    hydroxymethylglutaryl-CoA synthase activity GO:0004421 TAS
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
Biological Process
    kidney development GO:0001822 IEP
    liver development GO:0001889 IEP
    acetyl-CoA metabolic process GO:0006084 IBA
    acetyl-CoA metabolic process GO:0006084 ISO
    cholesterol biosynthetic process GO:0006695 IEA
    midgut development GO:0007494 IEP
    response to nutrient GO:0007584 IEP
    response to temperature stimulus GO:0009266 IEP
    response to xenobiotic stimulus GO:0009410 IEP
    response to bacterium GO:0009617 IEP
    response to metal ion GO:0010038 IEP
    farnesyl diphosphate biosynthetic process, mevalonate pathway GO:0010142 IBA
    response to organic cyclic compound GO:0014070 IEP
    lung development GO:0030324 IEP
    response to insulin GO:0032868 IEP
    cellular response to insulin stimulus GO:0032869 IEP
    cellular response to hormone stimulus GO:0032870 IEP
    multicellular organismal response to stress GO:0033555 IEP
    response to testosterone GO:0033574 IEP
    response to glucagon GO:0033762 IEP
    response to triglyceride GO:0034014 IEP
    response to monosaccharide GO:0034284 IEP
    response to prostaglandin F GO:0034696 IEP
    response to starvation GO:0042594 IEP
    response to peptide hormone GO:0043434 IEP
    response to ethanol GO:0045471 IEP
    ketone body biosynthetic process GO:0046951 IEP
    ketone body biosynthetic process GO:0046951 ISO
    ketone body biosynthetic process GO:0046951 TAS
    response to glucocorticoid GO:0051384 IEP
    response to cAMP GO:0051591 IEP
    response to growth hormone GO:0060416 IEP
    adipose tissue development GO:0060612 IEP
    response to fatty acid GO:0070542 IEP
    response to linoleic acid GO:0070543 IEP
    cellular response to lipopolysaccharide GO:0071222 IEP
    cellular response to amino acid stimulus GO:0071230 IEP
    cellular response to glucocorticoid stimulus GO:0071385 IEP
    cellular response to fatty acid GO:0071398 IEP
    cellular response to organic cyclic compound GO:0071407 IEP
Subcellular Localization
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISO
    mitochondrial matrix GO:0005759 IDA
 Experiment description of studies that identified Hmgcs2 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Hmgcs2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml



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