Gene description for Shank1
Gene name SH3/ankyrin domain gene 1
Gene symbol Shank1
Other names/aliases -
Species Mus musculus
 Database cross references - Shank1
ExoCarta ExoCarta_243961
Entrez Gene 243961
UniProt D3YZU1  
 Shank1 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Shank1
Molecular Function
    ankyrin repeat binding GO:0071532 ISO
    somatostatin receptor binding GO:0031877 ISO
    scaffold protein binding GO:0097110 ISO
    ionotropic glutamate receptor binding GO:0035255 ISO
    protein C-terminus binding GO:0008022 ISO
    receptor signaling complex scaffold activity GO:0030159 ISO
    GKAP/Homer scaffold activity GO:0030160 ISO
    identical protein binding GO:0042802 ISO
    protein complex binding GO:0032403 ISO
    SH3 domain binding GO:0017124 ISO
Biological Process
    determination of affect GO:0050894 ISO
    righting reflex GO:0060013 IMP
    nervous system development GO:0007399 IEA
    associative learning GO:0008306 IMP
    neuromuscular process controlling balance GO:0050885 IMP
    adult behavior GO:0030534 ISO
    regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity GO:2000311 IMP
    olfactory behavior GO:0042048 IMP
    cell differentiation GO:0030154 IEA
    synapse maturation GO:0060074 ISO
    vocalization behavior GO:0071625 ISO
    habituation GO:0046959 IMP
    social behavior GO:0035176 ISO
    long-term memory GO:0007616 IMP
    protein localization to synapse GO:0035418 IMP
    dendritic spine morphogenesis GO:0060997 IMP
    positive regulation of dendritic spine development GO:0060999 ISO
    protein complex assembly GO:0006461 ISO
    positive regulation of excitatory postsynaptic membrane potential GO:2000463 IMP
    negative regulation of actin filament bundle assembly GO:0032232 IDA
Subcellular Localization
    ionotropic glutamate receptor complex GO:0008328 IDA
    dendritic spine GO:0043197 ISO
    membrane GO:0016020 ISO
    cytoplasm GO:0005737 IEA
    postsynaptic membrane GO:0045211 ISO
    synapse GO:0045202 ISO
    cell junction GO:0030054 IEA
    dendrite GO:0030425 IDA
    plasma membrane GO:0005886 IDA
    N-methyl-D-aspartate selective glutamate receptor complex GO:0017146 ISO
    neuron projection GO:0043005 IDA
    neuronal postsynaptic density GO:0097481 IDA
    excitatory synapse GO:0060076 IDA
 Experiment description of studies that identified Shank1 in exosomes
1
Experiment ID 188
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|UCHL1|HSP90
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Shank1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Shank1 is involved
No pathways found





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