Gene description for Cyp4a2
Gene name cytochrome P450, family 4, subfamily a, polypeptide 2
Gene symbol Cyp4a2
Other names/aliases Cyp4a11
Species Rattus norvegicus
 Database cross references - Cyp4a2
ExoCarta ExoCarta_24306
Vesiclepedia VP_24306
Entrez Gene 24306
UniProt P20816  
 Cyp4a2 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Cyp4a2
Molecular Function
    monooxygenase activity GO:0004497 IEA
    fatty acid binding GO:0005504 IDA
    iron ion binding GO:0005506 IEA
    arachidonate monooxygenase activity GO:0008391 IBA
    arachidonate monooxygenase activity GO:0008391 IMP
    arachidonate 11,12-epoxygenase activity GO:0008405 TAS
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 IEA
    alkane 1-monooxygenase activity GO:0018685 IBA
    alkane 1-monooxygenase activity GO:0018685 IMP
    heme binding GO:0020037 IEA
    arachidonate binding GO:0050544 IDA
    long-chain fatty acid omega-hydroxylase activity GO:0102033 IEA
Biological Process
    kidney development GO:0001822 IBA
    kidney development GO:0001822 IEP
    response to xenobiotic stimulus GO:0009410 IEP
    response to hormone GO:0009725 IEP
    arachidonate metabolic process GO:0019369 IBA
    arachidonate metabolic process GO:0019369 IMP
    arachidonate metabolic process GO:0019369 TAS
    linoleic acid metabolic process GO:0043651 IBA
    linoleic acid metabolic process GO:0043651 IDA
    icosanoid biosynthetic process GO:0046456 IBA
    icosanoid biosynthetic process GO:0046456 IMP
    lauric acid metabolic process GO:0048252 IBA
    lauric acid metabolic process GO:0048252 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    membrane GO:0016020 IEA
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified Cyp4a2 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cyp4a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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