Gene description for Comt
Gene name	catechol-O-methyltransferase
Gene symbol	Comt
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Comt
ExoCarta	ExoCarta_24267
Vesiclepedia	VP_24267
Entrez Gene	24267
UniProt	P22734
Comt identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702
Reticulocytes	21828046

Gene ontology annotations for Comt

Molecular Function     magnesium ion binding GO:0000287 IEA     catechol O-methyltransferase activity GO:0016206 IBA     catechol O-methyltransferase activity GO:0016206 IDA     catechol O-methyltransferase activity GO:0016206 IEA     catechol O-methyltransferase activity GO:0016206 ISO Biological Process     behavioral fear response GO:0001662 ISO     response to hypoxia GO:0001666 ISO     kidney development GO:0001822 ISO     synaptic transmission, dopaminergic GO:0001963 ISO     startle response GO:0001964 ISO     response to amphetamine GO:0001975 ISO     renin secretion into blood stream GO:0002001 ISO     glycogen metabolic process GO:0005977 ISO     protein phosphorylation GO:0006468 ISO     protein methylation GO:0006479 ISO     catecholamine metabolic process GO:0006584 ISO     prostaglandin metabolic process GO:0006693 ISO     response to stress GO:0006950 ISO     response to oxidative stress GO:0006979 ISO     female pregnancy GO:0007565 IMP     learning or memory GO:0007611 ISO     learning GO:0007612 IMP     learning GO:0007612 ISO     memory GO:0007613 ISO     short-term memory GO:0007614 IMP     estrogen metabolic process GO:0008210 IMP     regulation of blood pressure GO:0008217 ISO     visual learning GO:0008542 ISO     response to temperature stimulus GO:0009266 ISO     response to xenobiotic stimulus GO:0009410 IEP     response to xenobiotic stimulus GO:0009410 ISO     response to wounding GO:0009611 ISO     response to toxic substance GO:0009636 ISO     gene expression GO:0010467 ISO     dopamine secretion GO:0014046 ISO     response to organic cyclic compound GO:0014070 IEP     cellular response to phosphate starvation GO:0016036 ISO     cerebellar cortex morphogenesis GO:0021696 ISO     response to food GO:0032094 ISO     methylation GO:0032259 IEA     methylation GO:0032259 ISO     methylation GO:0032259 ISS     response to lipopolysaccharide GO:0032496 IEP     developmental process GO:0032502 IBA     developmental process GO:0032502 IEA     glomerulus development GO:0032835 ISO     cholesterol efflux GO:0033344 ISO     multicellular organismal response to stress GO:0033555 ISO     response to cytokine GO:0034097 ISO     multicellular organism growth GO:0035264 ISO     exploration behavior GO:0035640 ISO     renal sodium excretion GO:0035812 ISO     norepinephrine metabolic process GO:0042415 ISO     dopamine metabolic process GO:0042417 IBA     dopamine metabolic process GO:0042417 IEA     dopamine metabolic process GO:0042417 ISO     dopamine catabolic process GO:0042420 ISO     catecholamine catabolic process GO:0042424 IBA     catecholamine catabolic process GO:0042424 IEA     catecholamine catabolic process GO:0042424 ISO     catecholamine catabolic process GO:0042424 ISS     fear response GO:0042596 ISO     response to estrogen GO:0043627 IEP     negative regulation of dopamine metabolic process GO:0045963 IMP     S-adenosylhomocysteine metabolic process GO:0046498 TAS     S-adenosylmethionine metabolic process GO:0046500 TAS     habituation GO:0046959 ISO     norepinephrine secretion GO:0048243 ISO     response to pain GO:0048265 IMP     negative regulation of smooth muscle cell proliferation GO:0048662 IMP     positive regulation of homocysteine metabolic process GO:0050668 IMP     cognition GO:0050890 ISO     detection of temperature stimulus involved in sensory perception of pain GO:0050965 ISO     response to corticosterone GO:0051412 ISO     artery development GO:0060840 ISO     cellular response to cocaine GO:0071314 ISO     mastication GO:0071626 ISO     renal albumin absorption GO:0097018 ISO     renal filtration GO:0097205 ISO     response to salt GO:1902074 ISO     response to dopamine GO:1903350 ISO     positive regulation of lactation GO:1903489 ISO     response to angiotensin GO:1990776 ISO Subcellular Localization     extracellular space GO:0005615 ISO     cytosol GO:0005829 ISO     cytosol GO:0005829 ISO     plasma membrane GO:0005886 IEA     membrane GO:0016020 IBA     axon GO:0030424 IBA     axon GO:0030424 IDA     dendrite GO:0030425 IBA     dendrite GO:0030425 IDA     vesicle GO:0031982 ISO     dendritic spine GO:0043197 IDA     intracellular membrane-bounded organelle GO:0043231 IEA     intracellular membrane-bounded organelle GO:0043231 ISO     cell body GO:0044297 IDA     cell body GO:0044297 ISO     postsynaptic membrane GO:0045211 IDA     glial cell projection GO:0097386 ISO     postsynapse GO:0098794 IDA     glutamatergic synapse GO:0098978 IDA