Gene description for Cbs
Gene name	cystathionine beta synthase
Gene symbol	Cbs
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Cbs
ExoCarta	ExoCarta_24250
Vesiclepedia	VP_24250
Entrez Gene	24250
UniProt	P32232
Cbs identified in sEVs derived from the following tissue/cell type
Hepatocytes	19367702

Gene ontology annotations for Cbs

Molecular Function     cystathionine beta-synthase activity GO:0004122 IBA     cystathionine beta-synthase activity GO:0004122 IEA     cystathionine beta-synthase activity GO:0004122 ISO     cystathionine beta-synthase activity GO:0004122 TAS     oxygen binding GO:0019825 ISO     enzyme binding GO:0019899 ISO     heme binding GO:0020037 ISO     pyridoxal phosphate binding GO:0030170 ISO     pyridoxal phosphate binding GO:0030170 ISS     pyridoxal phosphate binding GO:0030170 TAS     ubiquitin protein ligase binding GO:0031625 ISO     identical protein binding GO:0042802 ISO     protein homodimerization activity GO:0042803 ISO     protein homodimerization activity GO:0042803 ISS     metal ion binding GO:0046872 IEA     nitrite reductase (NO-forming) activity GO:0050421 ISO     carbon monoxide binding GO:0070025 ISO     nitric oxide binding GO:0070026 ISO     modified amino acid binding GO:0072341 ISO     S-adenosyl-L-methionine binding GO:1904047 ISO Biological Process     endochondral ossification GO:0001958 ISO     blood vessel remodeling GO:0001974 ISO     cysteine biosynthetic process from serine GO:0006535 IBA     cysteine biosynthetic process from serine GO:0006535 IEA     L-serine metabolic process GO:0006563 ISO     L-serine metabolic process GO:0006563 ISS     L-serine catabolic process GO:0006565 ISO     superoxide metabolic process GO:0006801 ISO     regulation of nitric oxide mediated signal transduction GO:0010749 ISO     cysteine biosynthetic process via cystathionine GO:0019343 IEA     cysteine biosynthetic process GO:0019344 ISO     cysteine biosynthetic process GO:0019344 ISO     transsulfuration GO:0019346 IDA     L-cysteine catabolic process GO:0019448 ISO     cerebellum morphogenesis GO:0021587 ISO     response to nutrient levels GO:0031667 IEP     DNA protection GO:0042262 ISO     negative regulation of apoptotic process GO:0043066 IDA     homocysteine catabolic process GO:0043418 ISO     homocysteine catabolic process GO:0043418 ISS     regulation of JUN kinase activity GO:0043506 ISO     homocysteine metabolic process GO:0050667 ISO     homocysteine metabolic process GO:0050667 ISO     homocysteine metabolic process GO:0050667 TAS     response to folic acid GO:0051593 ISO     maternal process involved in female pregnancy GO:0060135 ISO     cartilage development involved in endochondral bone morphogenesis GO:0060351 ISO     hydrogen sulfide biosynthetic process GO:0070814 IDA     hydrogen sulfide biosynthetic process GO:0070814 ISO     cellular response to hypoxia GO:0071456 IDA     blood vessel diameter maintenance GO:0097746 ISO Subcellular Localization     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IEA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     cytosol GO:0005829 TAS