Gene description for Tlr2
Gene name	toll-like receptor 2
Gene symbol	Tlr2
Other names/aliases	Ly105
Species	Mus musculus
Database cross references - Tlr2
ExoCarta	ExoCarta_24088
Vesiclepedia	VP_24088
Entrez Gene	24088
UniProt	Q9QUN7
Tlr2 identified in sEVs derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846

Gene ontology annotations for Tlr2

Molecular Function     lipopolysaccharide binding GO:0001530 ISO     amyloid-beta binding GO:0001540 IDA     amyloid-beta binding GO:0001540 ISO     transmembrane signaling receptor activity GO:0004888 IEA     protein binding GO:0005515 IPI     Toll-like receptor binding GO:0035325 ISO     signaling receptor activity GO:0038023 IBA     pattern recognition receptor activity GO:0038187 IMP     pattern recognition receptor activity GO:0038187 ISO     triacyl lipopeptide binding GO:0042497 IBA     triacyl lipopeptide binding GO:0042497 IDA     triacyl lipopeptide binding GO:0042497 ISO     diacyl lipopeptide binding GO:0042498 IDA     identical protein binding GO:0042802 ISO     peptidoglycan binding GO:0042834 ISO     protein-containing complex binding GO:0044877 IPI     protein-containing complex binding GO:0044877 ISO     NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 IEA     lipoteichoic acid binding GO:0070891 IDA     lipopeptide binding GO:0071723 ISO Biological Process     microglial cell activation GO:0001774 ISO     positive regulation of cytokine production GO:0001819 IGI     toll-like receptor signaling pathway GO:0002224 IBA     toll-like receptor signaling pathway GO:0002224 ISO     response to molecule of fungal origin GO:0002238 IMP     positive regulation of leukocyte migration GO:0002687 IMP     regulation of dendritic cell cytokine production GO:0002730 IDA     cell surface pattern recognition receptor signaling pathway GO:0002752 IMP     MyD88-dependent toll-like receptor signaling pathway GO:0002755 IGI     leukotriene metabolic process GO:0006691 ISO     nitric oxide biosynthetic process GO:0006809 IMP     defense response GO:0006952 IMP     inflammatory response GO:0006954 IBA     inflammatory response GO:0006954 IEA     I-kappaB phosphorylation GO:0007252 ISO     learning GO:0007612 IGI     negative regulation of cell population proliferation GO:0008285 ISO     response to bacterium GO:0009617 IMP     positive regulation of gene expression GO:0010628 ISO     macrophage cytokine production GO:0010934 IDA     macrophage cytokine production GO:0010934 IMP     microglia development GO:0014005 IGI     positive regulation of Wnt signaling pathway GO:0030177 ISO     negative regulation of actin filament polymerization GO:0030837 IGI     central nervous system myelin formation GO:0032289 ISO     response to bacterial lipoprotein GO:0032493 ISO     response to peptidoglycan GO:0032494 IMP     chemokine production GO:0032602 IMP     interleukin-17 production GO:0032620 IMP     interleukin-6 production GO:0032635 IDA     interleukin-6 production GO:0032635 IMP     tumor necrosis factor production GO:0032640 IMP     negative regulation of interleukin-12 production GO:0032695 IMP     negative regulation of interleukin-17 production GO:0032700 IMP     positive regulation of chemokine production GO:0032722 IMP     positive regulation of chemokine production GO:0032722 ISO     positive regulation of interferon-beta production GO:0032728 IDA     positive regulation of interleukin-1 beta production GO:0032731 IGI     positive regulation of interleukin-10 production GO:0032733 ISO     positive regulation of interleukin-12 production GO:0032735 IDA     positive regulation of interleukin-18 production GO:0032741 IDA     positive regulation of interleukin-6 production GO:0032755 IDA     positive regulation of interleukin-6 production GO:0032755 IDA     positive regulation of interleukin-6 production GO:0032755 IMP     positive regulation of interleukin-6 production GO:0032755 ISO     positive regulation of interleukin-8 production GO:0032757 ISO     positive regulation of interleukin-8 production GO:0032757 ISO     positive regulation of tumor necrosis factor production GO:0032760 IDA     positive regulation of tumor necrosis factor production GO:0032760 IGI     positive regulation of tumor necrosis factor production GO:0032760 IMP     toll-like receptor 2 signaling pathway GO:0034134 ISO     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 ISO     detection of triacyl bacterial lipopeptide GO:0042495 ISO     detection of diacyl bacterial lipopeptide GO:0042496 ISO     innate immune response GO:0045087 TAS     positive regulation of nitric oxide biosynthetic process GO:0045429 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     nitric oxide metabolic process GO:0046209 ISO     positive regulation of oligodendrocyte differentiation GO:0048714 ISO     positive regulation of inflammatory response GO:0050729 IGI     positive regulation of inflammatory response GO:0050729 ISO     negative regulation of phagocytosis GO:0050765 IGI     negative regulation of phagocytosis GO:0050765 IMP     defense response to Gram-positive bacterium GO:0050830 IMP     defense response to Gram-positive bacterium GO:0050830 ISO     leukocyte migration GO:0050900 IMP     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     negative regulation of synapse assembly GO:0051964 IGI     positive regulation of macrophage cytokine production GO:0060907 IDA     positive regulation of macrophage cytokine production GO:0060907 IMP     ERK1 and ERK2 cascade GO:0070371 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP     response to fatty acid GO:0070542 ISO     cellular response to bacterial lipopeptide GO:0071221 IMP     cellular response to bacterial lipopeptide GO:0071221 TAS     cellular response to lipoteichoic acid GO:0071223 IMP     cellular response to lipoteichoic acid GO:0071223 ISO     cellular response to lipoteichoic acid GO:0071223 ISO     cellular response to peptidoglycan GO:0071224 IMP     cellular response to type II interferon GO:0071346 ISO     cellular response to diacyl bacterial lipopeptide GO:0071726 ISO     cellular response to diacyl bacterial lipopeptide GO:0071726 ISO     cellular response to diacyl bacterial lipopeptide GO:0071726 ISS     cellular response to triacyl bacterial lipopeptide GO:0071727 ISO     cellular response to triacyl bacterial lipopeptide GO:0071727 ISO     cellular response to triacyl bacterial lipopeptide GO:0071727 ISS     xenophagy GO:0098792 IMP     positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISO     positive regulation of intracellular signal transduction GO:1902533 IMP     positive regulation of neutrophil migration GO:1902624 IMP     positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 ISO     positive regulation of xenophagy GO:1904417 IMP     positive regulation of matrix metallopeptidase secretion GO:1904466 ISO     neutrophil migration GO:1990266 IMP Subcellular Localization     cytoplasm GO:0005737 ISO     Golgi apparatus GO:0005794 ISO     Golgi apparatus GO:0005794 ISS     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     external side of plasma membrane GO:0009897 IDA     cell surface GO:0009986 ISO     phagocytic vesicle membrane GO:0030670 IEA     Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 ISO     Toll-like receptor 2-Toll-like receptor 6 protein complex GO:0035355 IPI     Toll-like receptor 2-Toll-like receptor 6 protein complex GO:0035355 ISO     cell projection GO:0042995 ISO     receptor complex GO:0043235 IBA     receptor complex GO:0043235 ISO     cell body GO:0044297 ISO     membrane raft GO:0045121 ISO     membrane raft GO:0045121 ISS