Gene description for Erc2
Gene name ELKS/RAB6-interacting/CAST family member 2
Gene symbol Erc2
Other names/aliases 6430531D06
CAST
CAST1/ERC2
D14Ertd171e
ELKS2alpha
Species Mus musculus
 Database cross references - Erc2
ExoCarta ExoCarta_238988
Entrez Gene 238988
UniProt Q6PH08  
 Erc2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Erc2
Molecular Function
    protein complex binding GO:0032403 ISO
    PDZ domain binding GO:0030165 ISO
    protein binding GO:0005515 IPI
Subcellular Localization
    growth cone GO:0030426 ISO
    postsynaptic density GO:0014069 ISO
    presynaptic membrane GO:0042734 ISO
    cell junction GO:0030054 IEA
    cytoskeleton GO:0005856 IEA
    neuron projection GO:0043005 IEA
    membrane GO:0016020 ISO
    terminal bouton GO:0043195 ISO
    protein complex GO:0043234 ISO
    neuronal cell body GO:0043025 ISO
    synapse GO:0045202 IDA
    cytoplasm GO:0005737 IEA
    presynaptic active zone GO:0048786 IEA
 Experiment description of studies that identified Erc2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Erc2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Erc2 is involved
No pathways found





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