Gene description for Gpc6
Gene name glypican 6
Gene symbol Gpc6
Other names/aliases -
Species Mus musculus
 Database cross references - Gpc6
ExoCarta ExoCarta_23888
Vesiclepedia VP_23888
Entrez Gene 23888
UniProt Q9R087  
 Gpc6 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Gpc6
Biological Process
    regulation of signal transduction GO:0009966 IEA
    cell migration GO:0016477 IBA
    cell migration GO:0016477 ISO
    cell migration GO:0016477 ISS
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 IBA
    regulation of neurotransmitter receptor localization to postsynaptic specialization membrane GO:0098696 ISO
Subcellular Localization
    extracellular region GO:0005576 IEA
    Golgi lumen GO:0005796 TAS
    plasma membrane GO:0005886 ISS
    cell surface GO:0009986 IBA
    synapse GO:0045202 EXP
    synapse GO:0045202 IBA
    synapse GO:0045202 IDA
    collagen-containing extracellular matrix GO:0062023 IEA
    side of membrane GO:0098552 IEA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Gpc6 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Gpc6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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