Gene description for Tusc5
Gene name tumor suppressor candidate 5
Gene symbol Tusc5
Other names/aliases C130069F04Rik
DSPB1
Lost1
Species Mus musculus
 Database cross references - Tusc5
ExoCarta ExoCarta_237858
Vesiclepedia VP_237858
Entrez Gene 237858
UniProt Q8C838  
 Tusc5 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Tusc5
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cellular response to insulin stimulus GO:0032869 IDA
    cellular response to insulin stimulus GO:0032869 IMP
    glucose import in response to insulin stimulus GO:0044381 IDA
    glucose import in response to insulin stimulus GO:0044381 IMP
    establishment of localization in cell GO:0051649 IMP
    protein localization to plasma membrane GO:0072659 IDA
    protein localization to plasma membrane GO:0072659 IMP
    vesicle fusion to plasma membrane GO:0099500 IMP
    endosome to plasma membrane protein transport GO:0099638 IDA
    endosome to plasma membrane protein transport GO:0099638 IMP
Subcellular Localization
    plasma membrane GO:0005886 IDA
    endomembrane system GO:0012505 IEA
    membrane GO:0016020 IBA
    cytoplasmic vesicle membrane GO:0030659 IDA
    cytoplasmic vesicle membrane GO:0030659 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified Tusc5 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tusc5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tusc5 is involved
No pathways found





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