Gene description for Ffar2
Gene name free fatty acid receptor 2
Gene symbol Ffar2
Other names/aliases GPCR43
Gpr43
Species Mus musculus
 Database cross references - Ffar2
ExoCarta ExoCarta_233079
Vesiclepedia VP_233079
Entrez Gene 233079
UniProt Q8VCK6  
 Ffar2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ffar2
Molecular Function
    G protein-coupled receptor activity GO:0004930 IBA
    G protein-coupled receptor activity GO:0004930 IDA
    G protein-coupled receptor activity GO:0004930 IMP
    G protein-coupled receptor activity GO:0004930 ISO
    lipid binding GO:0008289 IEA
Biological Process
    leukocyte chemotaxis involved in inflammatory response GO:0002232 IMP
    mucosal immune response GO:0002385 IMP
    regulation of acute inflammatory response GO:0002673 IMP
    positive regulation of cytokine production involved in immune response GO:0002720 IMP
    cell surface pattern recognition receptor signaling pathway GO:0002752 ISO
    cell surface pattern recognition receptor signaling pathway GO:0002752 ISS
    positive regulation of acute inflammatory response to non-antigenic stimulus GO:0002879 IMP
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    G protein-coupled receptor signaling pathway GO:0007186 IDA
    G protein-coupled receptor signaling pathway GO:0007186 IGI
    G protein-coupled receptor signaling pathway GO:0007186 IMP
    G protein-coupled receptor signaling pathway GO:0007186 ISO
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IDA
    lipid storage GO:0019915 IDA
    lipid storage GO:0019915 IMP
    positive regulation of insulin secretion GO:0032024 IDA
    positive regulation of chemokine production GO:0032722 IMP
    positive regulation of interleukin-8 production GO:0032757 ISO
    positive regulation of interleukin-8 production GO:0032757 ISS
    glucose homeostasis GO:0042593 IDA
    glucose homeostasis GO:0042593 IMP
    fat cell differentiation GO:0045444 IMP
    negative regulation of insulin secretion GO:0046676 IGI
    negative regulation of insulin secretion GO:0046676 IMP
    cellular response to fatty acid GO:0071398 IBA
    cellular response to fatty acid GO:0071398 IDA
    cellular response to fatty acid GO:0071398 IMP
    cellular response to fatty acid GO:0071398 ISO
    regulation of peptide hormone secretion GO:0090276 IDA
    regulation of peptide hormone secretion GO:0090276 IMP
    ligand-gated ion channel signaling pathway GO:1990806 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    cell projection GO:0042995 IEA
    cell projection GO:0042995 ISO
 Experiment description of studies that identified Ffar2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ffar2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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