Gene description for Ythdc1
Gene name YTH domain containing 1
Gene symbol Ythdc1
Other names/aliases A730098D12Rik
C80342
mKIAA1966
Species Mus musculus
 Database cross references - Ythdc1
ExoCarta ExoCarta_231386
Vesiclepedia VP_231386
Entrez Gene 231386
UniProt E9Q5K9  
 Ythdc1 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ythdc1
Molecular Function
    RNA binding GO:0003723 ISO
    RNA binding GO:0003723 ISS
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
    N6-methyladenosine-containing RNA reader activity GO:1990247 IBA
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISO
    N6-methyladenosine-containing RNA reader activity GO:1990247 ISS
Biological Process
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 IBA
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 IMP
    mRNA splicing, via spliceosome GO:0000398 IBA
    mRNA splicing, via spliceosome GO:0000398 ISO
    in utero embryonic development GO:0001701 IMP
    mRNA splice site recognition GO:0006376 ISO
    mRNA splice site recognition GO:0006376 ISS
    mRNA export from nucleus GO:0006406 ISO
    mRNA export from nucleus GO:0006406 ISS
    spermatogenesis GO:0007283 IMP
    dosage compensation by inactivation of X chromosome GO:0009048 ISO
    dosage compensation by inactivation of X chromosome GO:0009048 ISS
    post-transcriptional regulation of gene expression GO:0010608 IMP
    regulation of mRNA splicing, via spliceosome GO:0048024 ISO
    regulation of mRNA splicing, via spliceosome GO:0048024 ISS
    primary follicle stage GO:0048160 IMP
    mRNA alternative polyadenylation GO:0110104 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    nuclear body GO:0016604 ISO
    nuclear speck GO:0016607 ISO
    nuclear speck GO:0016607 ISS
 Experiment description of studies that identified Ythdc1 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ythdc1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atg16l1  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Ythdc1 is involved
No pathways found





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