Gene description for Rap1gds1
Gene name RAP1, GTP-GDP dissociation stimulator 1
Gene symbol Rap1gds1
Other names/aliases BC011279
GDS1
Species Mus musculus
 Database cross references - Rap1gds1
ExoCarta ExoCarta_229877
Vesiclepedia VP_229877
Entrez Gene 229877
 Rap1gds1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rap1gds1
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 ISO
    guanyl-nucleotide exchange factor activity GO:0005085 ISS
    GTPase regulator activity GO:0030695 IDA
    GTPase regulator activity GO:0030695 IMP
Biological Process
    cytokine production involved in inflammatory response GO:0002534 IMP
    cardiac muscle hypertrophy GO:0003300 IMP
    regulation of mitochondrion organization GO:0010821 IEA
    regulation of mitochondrion organization GO:0010821 ISO
    vascular associated smooth muscle contraction GO:0014829 IEA
    vascular associated smooth muscle contraction GO:0014829 ISO
    myosin filament assembly GO:0031034 IEA
    myosin filament assembly GO:0031034 ISO
    negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 IEA
    negative regulation of endoplasmic reticulum calcium ion concentration GO:0032471 ISO
    negative regulation of GTPase activity GO:0034260 IDA
    negative regulation of GTPase activity GO:0034260 IMP
    protein localization to nucleus GO:0034504 ISO
    protein localization to nucleus GO:0034504 ISS
    response to statin GO:0036273 IMP
    positive regulation of mitochondrial calcium ion concentration GO:0051561 IEA
    positive regulation of mitochondrial calcium ion concentration GO:0051561 ISO
    regulation of ERK5 cascade GO:0070376 IMP
    CAAX-box protein maturation GO:0080120 IEA
    CAAX-box protein maturation GO:0080120 ISO
    angiotensin-activated signaling pathway involved in heart process GO:0086098 IMP
    regulation of matrix metallopeptidase secretion GO:1904464 IMP
Subcellular Localization
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    mitochondrion GO:0005739 IEA
    mitochondrion GO:0005739 ISO
    endoplasmic reticulum GO:0005783 IEA
    endoplasmic reticulum GO:0005783 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Rap1gds1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rap1gds1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mapt  
Affinity Capture-MS Mus musculus
2 Kctd13  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Rap1gds1 is involved
No pathways found





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