Gene description for DKK1
Gene name	dickkopf WNT signaling pathway inhibitor 1
Gene symbol	DKK1
Other names/aliases	DKK-1 SK
Species	Homo sapiens
Database cross references - DKK1
ExoCarta	ExoCarta_22943
Entrez Gene	22943
HGNC	2891
MIM	605189
UniProt	O94907
DKK1 identified in exosomes derived from the following tissue/cell type
Hepatocytes	26054723
Mesenchymal stem cells	Unpublished / Not applicable

Gene ontology annotations for DKK1

Molecular Function     receptor antagonist activity GO:0048019 IDA     signal transducer activity GO:0004871 TAS     protein binding GO:0005515 IPI     growth factor activity GO:0008083 TAS     low-density lipoprotein particle receptor binding GO:0050750 IDA Biological Process     negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment GO:1901296 IDA     response to retinoic acid GO:0032526 IEA     positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway GO:0090082 ISS     negative regulation of skeletal muscle tissue development GO:0048642 IEA     negative regulation of peptidyl-serine phosphorylation GO:0033137 IDA     face morphogenesis GO:0060325 IEA     regulation of endodermal cell fate specification GO:0042663 IDA     negative regulation of canonical Wnt signaling pathway GO:0090090 TAS     negative regulation of cardiac muscle cell differentiation GO:2000726 IDA     regulation of receptor internalization GO:0002090 IDA     embryonic limb morphogenesis GO:0030326 IEA     negative regulation of protein complex assembly GO:0031333 IDA     hair follicle development GO:0001942 IEA     negative regulation of mesodermal cell fate specification GO:0042662 IDA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS     mesoderm formation GO:0001707 IEA     forebrain development GO:0030900 IEA     cell morphogenesis involved in differentiation GO:0000904 IEA     Wnt signaling pathway involved in somitogenesis GO:0090244 IEA     negative regulation of BMP signaling pathway GO:0030514 IEA     negative regulation of pathway-restricted SMAD protein phosphorylation GO:0060394 IDA     negative regulation of Wnt signaling pathway GO:0030178 IDA     endoderm formation GO:0001706 IEA     extracellular negative regulation of signal transduction GO:1900116 IDA Subcellular Localization     early endosome membrane GO:0031901 TAS     plasma membrane GO:0005886 IDA     extracellular space GO:0005615 IDA     extracellular region GO:0005576 TAS