Gene description for Gpr149
Gene name G protein-coupled receptor 149
Gene symbol Gpr149
Other names/aliases 9630018L10Rik
Ieda
PGR10
R35
Species Mus musculus
 Database cross references - Gpr149
ExoCarta ExoCarta_229357
Entrez Gene 229357
UniProt Q3UVY1  
 Gpr149 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Gpr149
Molecular Function
    neuropeptide binding GO:0042923 IBA
    signal transducer activity GO:0004871 IEA
    G-protein coupled receptor activity GO:0004930 IBA
    molecular_function GO:0003674 ND
Biological Process
    estrous cycle phase GO:0060206 IMP
    synaptic transmission GO:0007268 IBA
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 IBA
    antral ovarian follicle growth GO:0001547 IMP
    preantral ovarian follicle growth GO:0001546 IMP
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    negative regulation of ovulation GO:0060280 IMP
    signal transduction GO:0007165 IEA
    neuropeptide signaling pathway GO:0007218 IBA
Subcellular Localization
    integral component of plasma membrane GO:0005887 IBA
    integral component of membrane GO:0016021 IEA
    neuron projection GO:0043005 IBA
    cellular_component GO:0005575 ND
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Gpr149 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Gpr149
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gpr149 is involved
No pathways found





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