Gene description for Ambra1
Gene name autophagy/beclin 1 regulator 1
Gene symbol Ambra1
Other names/aliases 2310079H06Rik
A130023A14
AA474864
AV021921
D030051N19Rik
mKIAA1736
Species Mus musculus
 Database cross references - Ambra1
ExoCarta ExoCarta_228361
Entrez Gene 228361
UniProt A2AH22  
 Ambra1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ambra1
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 ISO
Biological Process
    positive regulation of mitochondrion degradation GO:1903599 ISO
    negative regulation of cell proliferation GO:0008285 IMP
    regulation of autophagosome assembly GO:2000785 ISO
    cell differentiation GO:0030154 IEA
    nervous system development GO:0007399 IEA
    multicellular organismal development GO:0007275 IEA
    positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 ISO
    negative regulation of neuron apoptotic process GO:0043524 IMP
    embryo development GO:0009790 IMP
    autophagy GO:0006914 IMP
    neural tube development GO:0021915 IMP
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 ISO
Subcellular Localization
    phagocytic vesicle GO:0045335 IDA
    axoneme GO:0005930 IDA
    cytoplasm GO:0005737 ISA
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 ISO
    cytoplasmic vesicle GO:0031410 IEA
 Experiment description of studies that identified Ambra1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ambra1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ambra1 is involved
No pathways found





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