Gene description for Slc30a1
Gene name solute carrier family 30 (zinc transporter), member 1
Gene symbol Slc30a1
Other names/aliases AI839647
C130040I11Rik
Znt1
Species Mus musculus
 Database cross references - Slc30a1
ExoCarta ExoCarta_22782
Vesiclepedia VP_22782
Entrez Gene 22782
UniProt Q60738  
 Slc30a1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc30a1
Molecular Function
    zinc ion transmembrane transporter activity GO:0005385 IBA
    zinc ion transmembrane transporter activity GO:0005385 ISO
    calcium channel inhibitor activity GO:0019855 IBA
    calcium channel inhibitor activity GO:0019855 IDA
    calcium channel inhibitor activity GO:0019855 ISO
    metal ion binding GO:0046872 IEA
    zinc:proton antiporter activity GO:0140826 ISO
    zinc:proton antiporter activity GO:0140826 ISS
Biological Process
    in utero embryonic development GO:0001701 IMP
    zinc ion transport GO:0006829 IDA
    zinc ion transport GO:0006829 ISO
    zinc ion transport GO:0006829 ISO
    intracellular calcium ion homeostasis GO:0006874 IDA
    intracellular zinc ion homeostasis GO:0006882 IBA
    intracellular zinc ion homeostasis GO:0006882 IDA
    intracellular zinc ion homeostasis GO:0006882 IMP
    detoxification of zinc ion GO:0010312 IBA
    defense response to bacterium GO:0042742 ISO
    defense response to bacterium GO:0042742 ISS
    negative regulation of neurotransmitter secretion GO:0046929 IEA
    negative regulation of neurotransmitter secretion GO:0046929 ISO
    positive regulation of dendritic spine morphogenesis GO:0061003 IEA
    positive regulation of dendritic spine morphogenesis GO:0061003 ISO
    zinc ion import into organelle GO:0062111 ISO
    zinc ion import into organelle GO:0062111 ISS
    calcium ion import GO:0070509 IEA
    calcium ion import GO:0070509 ISO
    cadmium ion transmembrane transport GO:0070574 IEA
    cadmium ion transmembrane transport GO:0070574 ISO
    zinc ion transmembrane transport GO:0071577 IBA
    negative regulation of zinc ion transmembrane import GO:0071584 IDA
    detoxification of cadmium ion GO:0071585 IEA
    detoxification of cadmium ion GO:0071585 ISO
    negative regulation of calcium ion import GO:0090281 IDA
    zinc export across plasma membrane GO:0140882 ISO
    zinc export across plasma membrane GO:0140882 ISS
    regulation of postsynaptic density protein 95 clustering GO:1902897 IEA
    regulation of postsynaptic density protein 95 clustering GO:1902897 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum GO:0005783 IBA
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 ISO
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    membrane GO:0016020 IBA
    basolateral plasma membrane GO:0016323 ISO
    basolateral plasma membrane GO:0016323 ISS
    T-tubule GO:0030315 IEA
    T-tubule GO:0030315 ISO
    dendrite GO:0030425 IEA
    dendrite GO:0030425 ISO
    cytoplasmic vesicle membrane GO:0030659 ISO
    cytoplasmic vesicle membrane GO:0030659 ISS
    nuclear membrane GO:0031965 IEA
    nuclear membrane GO:0031965 ISO
    Schaffer collateral - CA1 synapse GO:0098685 IEA
    Schaffer collateral - CA1 synapse GO:0098685 ISO
    postsynaptic density membrane GO:0098839 IEA
    postsynaptic density membrane GO:0098839 ISO
    postsynaptic density, intracellular component GO:0099092 IEA
    postsynaptic density, intracellular component GO:0099092 ISO
    glutamatergic postsynaptic density GO:0099573 IEA
    glutamatergic postsynaptic density GO:0099573 ISO
 Experiment description of studies that identified Slc30a1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc30a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Sstr3  
Proximity Label-MS Mus musculus
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