Gene description for Wnt11
Gene name wingless-type MMTV integration site family, member 11
Gene symbol Wnt11
Other names/aliases -
Species Mus musculus
 Database cross references - Wnt11
ExoCarta ExoCarta_22411
Entrez Gene 22411
UniProt P48615  
 Wnt11 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Wnt11
Molecular Function
    frizzled binding GO:0005109 IBA
    GTPase activator activity GO:0005096 ISO
    transcription regulatory region DNA binding GO:0044212 ISO
    protein binding GO:0005515 IPI
    protein kinase activator activity GO:0030295 ISO
    receptor binding GO:0005102 TAS
Biological Process
    protein phosphorylation GO:0006468 ISO
    negative regulation of cell death GO:0060548 ISO
    positive regulation of stress fiber assembly GO:0051496 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    artery morphogenesis GO:0048844 IMP
    multicellular organismal development GO:0007275 IEA
    non-canonical Wnt signaling pathway GO:0035567 IMP
    palate development GO:0060021 ISO
    bicellular tight junction assembly GO:0070830 IMP
    negative regulation of cell migration GO:0030336 ISO
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISO
    osteoblast differentiation GO:0001649 IGI
    neuron differentiation GO:0030182 IBA
    positive regulation of protein kinase activity GO:0045860 ISO
    neuroendocrine cell differentiation GO:0061101 ISO
    kidney development GO:0001822 IDA
    positive regulation of apoptotic process GO:0043065 IMP
    positive regulation of GTPase activity GO:0043547 ISO
    negative regulation of mesenchymal cell proliferation GO:0072201 IMP
    cell-cell signaling GO:0007267 TAS
    negative regulation of fibroblast growth factor production GO:0090272 IMP
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    canonical Wnt signaling pathway GO:0060070 IDA
    positive regulation of protein kinase C signaling GO:0090037 ISO
    protein localization to cell surface GO:0034394 ISO
    signal transduction GO:0007165 TAS
    Wnt signaling pathway GO:0016055 IEA
    positive regulation of transforming growth factor beta2 production GO:0032915 IMP
    cell fate commitment GO:0045165 IBA
    bone mineralization GO:0030282 IGI
    outflow tract morphogenesis GO:0003151 IMP
    negative regulation of cell growth GO:0030308 ISO
    positive regulation of gene expression GO:0010628 ISO
    ventricular septum morphogenesis GO:0060412 IMP
    organ morphogenesis GO:0009887 TAS
    positive regulation of cell migration GO:0030335 ISO
Subcellular Localization
    extracellular region GO:0005576 IDA
    proteinaceous extracellular matrix GO:0005578 IDA
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Wnt11 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Wnt11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Wnt11 is involved
PathwayEvidenceSource
Ca2+ pathway IEA Reactome
PCP/CE pathway IEA Reactome
WNT ligand biogenesis and trafficking IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here