Gene description for Fmnl3
Gene name formin-like 3
Gene symbol Fmnl3
Other names/aliases 2700073B04Rik
FBP11
Wbp3
mKIAA2014
Species Mus musculus
 Database cross references - Fmnl3
ExoCarta ExoCarta_22379
Vesiclepedia VP_22379
Entrez Gene 22379
UniProt Q6ZPF4  
 Fmnl3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Fmnl3
Molecular Function
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IEA
    GTPase activating protein binding GO:0032794 IDA
    actin filament binding GO:0051015 IBA
Biological Process
    angiogenesis GO:0001525 IEA
    cytoskeleton organization GO:0007010 ISO
    cytoskeleton organization GO:0007010 ISS
    regulation of cell shape GO:0008360 IBA
    regulation of cell shape GO:0008360 ISO
    regulation of cell shape GO:0008360 ISS
    cell migration GO:0016477 IBA
    cell migration GO:0016477 ISO
    cell migration GO:0016477 ISS
    actin cytoskeleton organization GO:0030036 IEA
    actin cytoskeleton organization GO:0030036 ISO
    cortical actin cytoskeleton organization GO:0030866 IBA
    filopodium assembly GO:0046847 IEA
    filopodium assembly GO:0046847 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Fmnl3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Fmnl3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Zbtb7b  
Affinity Capture-MS Mus musculus
2 Prpf18  
Co-fractionation Mus musculus
3 Diap2  
Co-fractionation Mus musculus
4 Eed  
Affinity Capture-MS Mus musculus
5 Csrp3  
Co-fractionation Mus musculus
6 Fmnl1 57778
Co-fractionation Mus musculus
7 Daam1 208846
Co-fractionation Mus musculus
8 Diap3  
Co-fractionation Mus musculus
9 Fmnl2 71409
Co-fractionation Mus musculus
10 Fmn1  
Co-fractionation Mus musculus
11 Diap1 13367
Co-fractionation Mus musculus
12 Daam2  
Co-fractionation Mus musculus
13 Fhdc1 229474
Co-fractionation Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here