Gene description for Vnn1
Gene name vanin 1
Gene symbol Vnn1
Other names/aliases V-1
Species Mus musculus
 Database cross references - Vnn1
ExoCarta ExoCarta_22361
Vesiclepedia VP_22361
Entrez Gene 22361
UniProt Q9Z0K8  
 Vnn1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Vnn1
Molecular Function
    pantetheine hydrolase activity GO:0017159 IBA
    pantetheine hydrolase activity GO:0017159 IDA
    pantetheine hydrolase activity GO:0017159 ISO
    pantetheine hydrolase activity GO:0017159 ISS
    GPI anchor binding GO:0034235 TAS
Biological Process
    acute inflammatory response GO:0002526 IDA
    chronic inflammatory response GO:0002544 IDA
    inflammatory response GO:0006954 IMP
    coenzyme A catabolic process GO:0015938 IMP
    pantothenate metabolic process GO:0015939 IBA
    pantothenate metabolic process GO:0015939 ISO
    pantothenate metabolic process GO:0015939 ISS
    positive regulation of T cell differentiation in thymus GO:0033089 IDA
    innate immune response GO:0045087 IDA
    cell-cell adhesion GO:0098609 IDA
    positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902177 IMP
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 TAS
    plasma membrane GO:0005886 IEA
    membrane GO:0016020 TAS
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified Vnn1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Vnn1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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