Gene description for Vasp
Gene name vasodilator-stimulated phosphoprotein
Gene symbol Vasp
Other names/aliases -
Species Mus musculus
 Database cross references - Vasp
ExoCarta ExoCarta_22323
Vesiclepedia VP_22323
Entrez Gene 22323
UniProt P70460  
 Vasp identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Vasp
Molecular Function
    actin binding GO:0003779 IEA
    protein binding GO:0005515 IPI
    profilin binding GO:0005522 IBA
    profilin binding GO:0005522 IEA
    profilin binding GO:0005522 ISO
    SH3 domain binding GO:0017124 IEA
Biological Process
    neural tube closure GO:0001843 IBA
    neural tube closure GO:0001843 IGI
    axon guidance GO:0007411 IBA
    axon guidance GO:0007411 IGI
    actin polymerization or depolymerization GO:0008154 IBA
    actin polymerization or depolymerization GO:0008154 IEA
    actin cytoskeleton organization GO:0030036 IGI
    positive regulation of actin filament polymerization GO:0030838 IBA
    positive regulation of actin filament polymerization GO:0030838 IEA
    positive regulation of actin filament polymerization GO:0030838 ISO
    protein homotetramerization GO:0051289 IEA
Subcellular Localization
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
    cytoskeleton GO:0005856 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    bicellular tight junction GO:0005923 IEA
    focal adhesion GO:0005925 IBA
    focal adhesion GO:0005925 IDA
    focal adhesion GO:0005925 ISO
    lamellipodium GO:0030027 IDA
    filopodium GO:0030175 IDA
    lamellipodium membrane GO:0031258 IEA
    filopodium membrane GO:0031527 IEA
    postsynapse GO:0098794 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified Vasp in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Vasp
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tmem173  
Proximity Label-MS Mus musculus
2 Ppp4r2  
Co-fractionation Mus musculus
3 Atg16l1  
Affinity Capture-MS Mus musculus
4 Pfn2  
Affinity Capture-Western Mus musculus
Reconstituted Complex Mus musculus
5 TRIM9  
Reconstituted Complex Homo sapiens
6 Trim9  
Reconstituted Complex Mus musculus
Co-fractionation Mus musculus
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here