Gene description for Upp1
Gene name uridine phosphorylase 1
Gene symbol Upp1
Other names/aliases AI325217
UPase
UdRPase
Up
Upp
Species Mus musculus
 Database cross references - Upp1
ExoCarta ExoCarta_22271
Vesiclepedia VP_22271
Entrez Gene 22271
UniProt P52624  
 Upp1 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Upp1
Molecular Function
    uridine phosphorylase activity GO:0004850 IBA
    uridine phosphorylase activity GO:0004850 IDA
    uridine phosphorylase activity GO:0004850 IMP
    uridine phosphorylase activity GO:0004850 ISO
    thymidine phosphorylase activity GO:0009032 IMP
    thymidine phosphorylase activity GO:0009032 IMP
    identical protein binding GO:0042802 ISO
    identical protein binding GO:0042802 ISS
    deoxyuridine phosphorylase activity GO:0047847 IDA
Biological Process
    uridine catabolic process GO:0006218 IBA
    uridine catabolic process GO:0006218 IDA
    uridine catabolic process GO:0006218 ISO
    pyrimidine nucleotide metabolic process GO:0006220 IMP
    CMP catabolic process GO:0006248 IDA
    dCMP catabolic process GO:0006249 IDA
    cellular response to glucose starvation GO:0042149 IEA
    UMP salvage GO:0044206 IEA
    UMP salvage GO:0044206 IMP
    UMP catabolic process GO:0046050 IDA
    dTMP catabolic process GO:0046074 IMP
    dTMP catabolic process GO:0046074 IMP
    dUMP catabolic process GO:0046079 IDA
    uridine metabolic process GO:0046108 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Upp1 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Upp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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