Gene description for Umps
Gene name uridine monophosphate synthetase
Gene symbol Umps
Other names/aliases 1700095D23Rik
AA408257
AL033308
BB164745
Species Mus musculus
 Database cross references - Umps
ExoCarta ExoCarta_22247
Vesiclepedia VP_22247
Entrez Gene 22247
UniProt P13439  
 Umps identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Umps
Molecular Function
    orotate phosphoribosyltransferase activity GO:0004588 IBA
    orotate phosphoribosyltransferase activity GO:0004588 IDA
    orotate phosphoribosyltransferase activity GO:0004588 ISO
    orotidine-5'-phosphate decarboxylase activity GO:0004590 IBA
    orotidine-5'-phosphate decarboxylase activity GO:0004590 IDA
    orotidine-5'-phosphate decarboxylase activity GO:0004590 ISO
    identical protein binding GO:0042802 ISO
Biological Process
    'de novo' pyrimidine nucleobase biosynthetic process GO:0006207 IEA
    UMP biosynthetic process GO:0006222 IBA
    UMP biosynthetic process GO:0006222 ISO
    UDP biosynthetic process GO:0006225 IDA
    UDP biosynthetic process GO:0006225 IMP
    female pregnancy GO:0007565 IEA
    lactation GO:0007595 IEA
    pyrimidine nucleobase biosynthetic process GO:0019856 IBA
    'de novo' UMP biosynthetic process GO:0044205 IDA
    'de novo' UMP biosynthetic process GO:0044205 IEA
    'de novo' UMP biosynthetic process GO:0044205 IMP
    cellular response to xenobiotic stimulus GO:0071466 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IEA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Umps in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Umps
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
2 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
3 Eed  
Affinity Capture-MS Mus musculus
4 Fitm2  
Positive Genetic Mus musculus
View the network image/svg+xml
 Pathways in which Umps is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Metabolism of nucleotides IEA Reactome
Nucleotide biosynthesis IEA Reactome
Pyrimidine biosynthesis IEA Reactome





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