Gene description for Umod
Gene name	uromodulin
Gene symbol	Umod
Other names/aliases	THP Urehd1 urehr4
Species	Mus musculus
Database cross references - Umod
ExoCarta	ExoCarta_22242
Vesiclepedia	VP_22242
Entrez Gene	22242
UniProt	Q91X17
Umod identified in sEVs derived from the following tissue/cell type
Faeces	33431899
Faeces	33431899

Gene ontology annotations for Umod

Molecular Function     calcium ion binding GO:0005509 IEA     protein binding GO:0005515 IPI     IgG binding GO:0019864 IEA     IgG binding GO:0019864 ISO Biological Process     kidney development GO:0001822 IMP     organ or tissue specific immune response GO:0002251 IMP     renal water homeostasis GO:0003091 IMP     glomerular filtration GO:0003094 IMP     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 IMP     lipid metabolic process GO:0006629 IMP     intracellular calcium ion homeostasis GO:0006874 IMP     intracellular sodium ion homeostasis GO:0006883 IMP     autophagy GO:0006914 IMP     apoptotic process GO:0006915 IMP     inflammatory response GO:0006954 IMP     response to unfolded protein GO:0006986 IMP     endoplasmic reticulum organization GO:0007029 IMP     heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IEA     heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISO     leukocyte cell-cell adhesion GO:0007159 IEA     leukocyte cell-cell adhesion GO:0007159 ISO     regulation of blood pressure GO:0008217 IMP     RNA splicing GO:0008380 IMP     response to xenobiotic stimulus GO:0009410 IMP     response to water deprivation GO:0009414 IMP     gene expression GO:0010467 IMP     urate transport GO:0015747 IMP     peptidyl-threonine phosphorylation GO:0018107 IMP     intracellular phosphate ion homeostasis GO:0030643 IMP     intracellular chloride ion homeostasis GO:0030644 IDA     intracellular chloride ion homeostasis GO:0030644 IMP     response to lipopolysaccharide GO:0032496 IDA     chemokine production GO:0032602 IMP     tumor necrosis factor-mediated signaling pathway GO:0033209 IMP     cellular response to stress GO:0033554 IMP     multicellular organismal response to stress GO:0033555 IMP     cellular response to unfolded protein GO:0034620 IMP     response to endoplasmic reticulum stress GO:0034976 IMP     regulation of urine volume GO:0035809 IMP     response to diuretic GO:0036270 IMP     ERAD pathway GO:0036503 IMP     protein transport into plasma membrane raft GO:0044861 IMP     citric acid secretion GO:0046720 IMP     multicellular organismal-level homeostasis GO:0048871 IMP     chemical homeostasis GO:0048878 IMP     monoatomic ion homeostasis GO:0050801 IMP     defense response to Gram-negative bacterium GO:0050829 IMP     defense response to Gram-negative bacterium GO:0050829 ISO     defense response to Gram-negative bacterium GO:0050829 ISS     multicellular organismal-level water homeostasis GO:0050891 IMP     regulation of protein transport GO:0051223 IMP     phosphate ion homeostasis GO:0055062 IMP     chloride ion homeostasis GO:0055064 IMP     calcium ion homeostasis GO:0055074 IMP     potassium ion homeostasis GO:0055075 IMP     sodium ion homeostasis GO:0055078 IMP     micturition GO:0060073 IMP     chaperone-mediated protein folding GO:0061077 IMP     renal sodium ion absorption GO:0070294 IDA     renal sodium ion absorption GO:0070294 IMP     urea transmembrane transport GO:0071918 IMP     collecting duct development GO:0072044 IMP     juxtaglomerular apparatus development GO:0072051 IMP     loop of Henle development GO:0072070 IMP     metanephric ascending thin limb development GO:0072218 IEP     metanephric distal convoluted tubule development GO:0072221 IEP     metanephric thick ascending limb development GO:0072233 IEP     protein localization to vacuole GO:0072665 IMP     apoptotic signaling pathway GO:0097190 IMP     connective tissue replacement GO:0097709 IMP     renal urate salt excretion GO:0097744 IMP     antibacterial innate immune response GO:0140367 ISO     antibacterial innate immune response GO:0140367 ISS     neutrophil migration GO:1990266 IBA     neutrophil migration GO:1990266 IEA     neutrophil migration GO:1990266 ISO Subcellular Localization     spindle pole GO:0000922 ISO     spindle pole GO:0000922 ISS     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     endoplasmic reticulum GO:0005783 IDA     plasma membrane GO:0005886 IDA     cilium GO:0005929 IDA     cilium GO:0005929 ISO     cilium GO:0005929 ISS     cell surface GO:0009986 IBA     membrane GO:0016020 ISO     membrane GO:0016020 ISS     basolateral plasma membrane GO:0016323 ISO     basolateral plasma membrane GO:0016323 ISS     apical plasma membrane GO:0016324 IBA     apical plasma membrane GO:0016324 IDA     apical plasma membrane GO:0016324 ISO     apical plasma membrane GO:0016324 ISS     apical part of cell GO:0045177 ISO     ciliary membrane GO:0060170 IEA     side of membrane GO:0098552 IEA