Gene description for Ugdh
Gene name UDP-glucose dehydrogenase
Gene symbol Ugdh
Other names/aliases Udpgdh
Species Mus musculus
 Database cross references - Ugdh
ExoCarta ExoCarta_22235
Vesiclepedia VP_22235
Entrez Gene 22235
UniProt O70475  
 Ugdh identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ugdh
Molecular Function
    UDP-glucose 6-dehydrogenase activity GO:0003979 IDA
    UDP-glucose 6-dehydrogenase activity GO:0003979 IMP
    UDP-glucose 6-dehydrogenase activity GO:0003979 ISO
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    NAD binding GO:0051287 IEA
Biological Process
    gastrulation with mouth forming second GO:0001702 IMP
    gastrulation with mouth forming second GO:0001702 IMP
    glycosaminoglycan biosynthetic process GO:0006024 IBA
    UDP-glucuronate biosynthetic process GO:0006065 IEA
    UDP-glucuronate biosynthetic process GO:0006065 IMP
    UDP-glucuronate biosynthetic process GO:0006065 ISO
    UDP-glucuronate biosynthetic process GO:0006065 ISS
    heparan sulfate proteoglycan biosynthetic process GO:0015012 IMP
    chondroitin sulfate biosynthetic process GO:0030206 IMP
    protein hexamerization GO:0034214 ISO
    protein hexamerization GO:0034214 ISS
    neuron development GO:0048666 ISO
    neuron development GO:0048666 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Ugdh in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ugdh
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Rpusd2  
Co-fractionation Mus musculus
2 Mettl21e  
Affinity Capture-MS Mus musculus
3 Rnaseh2a  
Co-fractionation Mus musculus
4 Ncapd2 68298
Co-fractionation Mus musculus
5 Sirt3  
Co-fractionation Mus musculus
6 Fancd2  
Affinity Capture-MS Mus musculus
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