Gene description for Tpbg
Gene name trophoblast glycoprotein
Gene symbol Tpbg
Other names/aliases 5T4
AW495680
WAIF1
Species Mus musculus
 Database cross references - Tpbg
ExoCarta ExoCarta_21983
Vesiclepedia VP_21983
Entrez Gene 21983
UniProt Q9Z0L0  
 Tpbg identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tpbg
Biological Process
    negative regulation of cell population proliferation GO:0008285 IGI
    olfactory learning GO:0008355 IMP
    positive regulation of chemotaxis GO:0050921 IGI
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IGI
    synaptic transmission, GABAergic GO:0051932 IMP
    positive regulation of synapse assembly GO:0051965 IDA
    cell chemotaxis GO:0060326 IMP
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IGI
    protein localization to plasma membrane GO:0072659 IMP
    negative regulation of canonical Wnt signaling pathway GO:0090090 IBA
    mesenchymal cell migration GO:0090497 IMP
    dendrite arborization GO:0140059 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 IMP
    dendrite GO:0030425 IDA
    axon terminus GO:0043679 IDA
 Experiment description of studies that identified Tpbg in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tpbg
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tpbg is involved
No pathways found





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