Gene description for Cd40lg
Gene name	CD40 ligand
Gene symbol	Cd40lg
Other names/aliases	CD154 CD40-L Cd40l HIGM1 IGM IMD3 Ly-62 Ly62 T-BAM TRAP Tnfsf5 gp39
Species	Mus musculus
Database cross references - Cd40lg
ExoCarta	ExoCarta_21947
Vesiclepedia	VP_21947
Entrez Gene	21947
UniProt	P27548
Cd40lg identified in sEVs derived from the following tissue/cell type
Mast cells	11145662

Gene ontology annotations for Cd40lg

Molecular Function     cytokine activity GO:0005125 IBA     cytokine activity GO:0005125 IEA     tumor necrosis factor receptor binding GO:0005164 IEA     CD40 receptor binding GO:0005174 ISO     CD40 receptor binding GO:0005174 ISS     integrin binding GO:0005178 IEA     integrin binding GO:0005178 ISO     protein serine/threonine kinase activator activity GO:0043539 ISO     protein serine/threonine kinase activator activity GO:0043539 ISS Biological Process     immunoglobulin production GO:0002377 IGI     regulation of immunoglobulin production GO:0002637 IDA     positive regulation of immune response to tumor cell GO:0002839 ISO     inflammatory response GO:0006954 ISO     inflammatory response GO:0006954 ISS     signal transduction GO:0007165 NAS     cell surface receptor signaling pathway GO:0007166 IBA     integrin-mediated signaling pathway GO:0007229 IEA     integrin-mediated signaling pathway GO:0007229 ISO     positive regulation of gene expression GO:0010628 ISO     CD40 signaling pathway GO:0023035 IEA     CD40 signaling pathway GO:0023035 ISO     platelet activation GO:0030168 ISO     platelet activation GO:0030168 ISS     B cell differentiation GO:0030183 IGI     positive regulation of B cell proliferation GO:0030890 ISO     positive regulation of type II interferon production GO:0032729 ISO     positive regulation of interleukin-10 production GO:0032733 ISO     positive regulation of interleukin-10 production GO:0032733 ISS     positive regulation of interleukin-12 production GO:0032735 IEA     positive regulation of interleukin-12 production GO:0032735 ISO     positive regulation of interleukin-4 production GO:0032753 ISO     positive regulation of interleukin-4 production GO:0032753 ISS     B cell proliferation GO:0042100 ISO     B cell proliferation GO:0042100 ISS     positive regulation of T cell proliferation GO:0042102 ISO     positive regulation of T cell proliferation GO:0042102 ISS     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISS     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA     isotype switching GO:0045190 IDA     positive regulation of MHC class II biosynthetic process GO:0045348 ISO     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISS     dendritic cell differentiation GO:0097028 ISO     positive regulation of endothelial cell apoptotic process GO:2000353 IEA     positive regulation of endothelial cell apoptotic process GO:2000353 ISO     positive regulation of dendritic cell differentiation GO:2001200 ISO     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IBA Subcellular Localization     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IEA     extracellular space GO:0005615 ISO     Golgi apparatus GO:0005794 IEA     Golgi apparatus GO:0005794 ISO     plasma membrane GO:0005886 ISO     external side of plasma membrane GO:0009897 IDA     cell surface GO:0009986 ISO     cell projection GO:0042995 ISO     cell body GO:0044297 ISO