Gene description for Cd40
Gene name	CD40 antigen
Gene symbol	Cd40
Other names/aliases	AI326936 Bp50 GP39 HIGM1 IGM IMD3 T-BAM TRAP Tnfrsf5 p50
Species	Mus musculus
Database cross references - Cd40
ExoCarta	ExoCarta_21939
Vesiclepedia	VP_21939
Entrez Gene	21939
UniProt	P27512
Cd40 identified in sEVs derived from the following tissue/cell type
Macrophages	23658846
Macrophages	23658846
Macrophages	23658846
Mast cells	11145662

Gene ontology annotations for Cd40

Molecular Function     antigen binding GO:0003823 ISO     protein binding GO:0005515 IPI     enzyme binding GO:0019899 ISO     protein domain specific binding GO:0019904 ISO     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase binding GO:0031625 ISO     signaling receptor activity GO:0038023 IEA Biological Process     positive regulation of protein phosphorylation GO:0001934 ISO     immunoglobulin production GO:0002377 IGI     regulation of immunoglobulin production GO:0002637 IDA     immune response-regulating cell surface receptor signaling pathway GO:0002768 IBA     immune response-regulating cell surface receptor signaling pathway GO:0002768 IDA     intracellular calcium ion homeostasis GO:0006874 IMP     intracellular calcium ion homeostasis GO:0006874 ISO     cell surface receptor signaling pathway via JAK-STAT GO:0007259 IEA     B cell mediated immunity GO:0019724 IGI     CD40 signaling pathway GO:0023035 IGI     CD40 signaling pathway GO:0023035 ISO     positive regulation of B cell proliferation GO:0030890 IDA     positive regulation of B cell proliferation GO:0030890 IGI     interleukin-12 production GO:0032615 IDA     positive regulation of interleukin-12 production GO:0032735 IDA     B cell proliferation GO:0042100 IDA     B cell proliferation GO:0042100 IGI     B cell activation GO:0042113 IBA     B cell activation GO:0042113 IDA     B cell activation GO:0042113 ISO     positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 ISO     defense response to protozoan GO:0042832 IDA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     positive regulation of MAP kinase activity GO:0043406 ISO     positive regulation of MAPK cascade GO:0043410 IEA     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IDA     positive regulation of blood vessel endothelial cell migration GO:0043536 IEA     positive regulation of blood vessel endothelial cell migration GO:0043536 ISO     positive regulation of GTPase activity GO:0043547 ISO     positive regulation of angiogenesis GO:0045766 IEA     positive regulation of angiogenesis GO:0045766 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of isotype switching to IgG isotypes GO:0048304 IDA     regulation of immune response GO:0050776 IDA     positive regulation of NF-kappaB transcription factor activity GO:0051092 ISO     defense response to virus GO:0051607 IDA     cellular response to mechanical stimulus GO:0071260 IEA     positive regulation of protein kinase C signaling GO:0090037 IEA     positive regulation of protein kinase C signaling GO:0090037 ISO     positive regulation of interleukin-4-mediated signaling pathway GO:1902216 IEA     positive regulation of endothelial cell apoptotic process GO:2000353 IEA     positive regulation of endothelial cell apoptotic process GO:2000353 ISO Subcellular Localization     extracellular region GO:0005576 IEA     extracellular space GO:0005615 ISO     plasma membrane GO:0005886 IDA     external side of plasma membrane GO:0009897 IBA     external side of plasma membrane GO:0009897 IDA     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     CD40 receptor complex GO:0035631 IBA     CD40 receptor complex GO:0035631 IDA     neuronal cell body GO:0043025 ISO     varicosity GO:0043196 ISO     intracellular membrane-bounded organelle GO:0043231 IDA