Gene description for Gmds
Gene name GDP-mannose 4, 6-dehydratase
Gene symbol Gmds
Other names/aliases BC031788
C87208
Species Mus musculus
 Database cross references - Gmds
ExoCarta ExoCarta_218138
Vesiclepedia VP_218138
Entrez Gene 218138
UniProt Q8K0C9  
 Gmds identified in sEVs derived from the following tissue/cell type
Melanoma cells 34957415    
Melanoma cells 34957415    
 Gene ontology annotations for Gmds
Molecular Function
    GDP-mannose 4,6-dehydratase activity GO:0008446 IBA
    GDP-mannose 4,6-dehydratase activity GO:0008446 IDA
    GDP-mannose 4,6-dehydratase activity GO:0008446 ISO
    GDP-mannose 4,6-dehydratase activity GO:0008446 ISS
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    NADP+ binding GO:0070401 ISO
    NADP+ binding GO:0070401 ISS
Biological Process
    Notch signaling pathway GO:0007219 ISS
    GDP-mannose metabolic process GO:0019673 ISO
    GDP-mannose metabolic process GO:0019673 ISS
    'de novo' GDP-L-fucose biosynthetic process GO:0042351 IBA
    'de novo' GDP-L-fucose biosynthetic process GO:0042351 IEA
    'de novo' GDP-L-fucose biosynthetic process GO:0042351 ISO
    'de novo' GDP-L-fucose biosynthetic process GO:0042351 ISS
Subcellular Localization
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Gmds in sEVs
1
Experiment ID 1117
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 1118
MISEV standards
Biophysical techniques
Cd81|Icam1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34957415    
Organism Mus musculus
Experiment description Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Authors "García-Silva S, Benito-Martín A, Nogués L, Hernández-Barranco A, Mazariegos MS, Santos V, Hergueta-Redondo M, Ximénez-Embún P, Kataru RP, Lopez AA, Merino C, Sánchez-Redondo S, Graña-Castro O, Matei I, Nicolás-Avila JÁ, Torres-Ruiz R, Rodríguez-Perales S, Martínez L, Pérez-Martínez M, Mata G, Szumera-Ciećkiewicz A, Kalinowska I, Saltari A, Martínez-Gómez JM, Hogan SA, Saragovi HU, Ortega S, Garcia-Martin C, Boskovic J, Levesque MP, Rutkowski P, Hidalgo A, Muñoz J, Megías D, Mehrara BJ, Lyden D, Peinado H."
Journal name Nat Cancer
Publication year 2021
Sample Melanoma cells
Sample name B16-F1R2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Gmds
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tatdn1  
Co-fractionation Mus musculus
View the network image/svg+xml



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