Gene description for Tgfb1
Gene name	transforming growth factor, beta 1
Gene symbol	Tgfb1
Other names/aliases	TGF-beta1 TGFbeta1 Tgfb Tgfb-1
Species	Mus musculus
Database cross references - Tgfb1
ExoCarta	ExoCarta_21803
Vesiclepedia	VP_21803
Entrez Gene	21803
UniProt	P04202
Tgfb1 identified in sEVs derived from the following tissue/cell type
Brain cancer cells	19109410

Gene ontology annotations for Tgfb1

Molecular Function     antigen binding GO:0003823 ISO     type II transforming growth factor beta receptor binding GO:0005114 ISO     type II transforming growth factor beta receptor binding GO:0005114 ISS     cytokine activity GO:0005125 IBA     cytokine activity GO:0005125 IEA     cytokine activity GO:0005125 ISO     transforming growth factor beta receptor binding GO:0005160 IPI     transforming growth factor beta receptor binding GO:0005160 TAS     protein binding GO:0005515 IPI     protein binding GO:0005515 ISS     growth factor activity GO:0008083 IEA     growth factor activity GO:0008083 ISO     enzyme binding GO:0019899 IEA     enzyme binding GO:0019899 ISO     type I transforming growth factor beta receptor binding GO:0034713 ISO     type I transforming growth factor beta receptor binding GO:0034713 ISS     type III transforming growth factor beta receptor binding GO:0034714 ISO     type III transforming growth factor beta receptor binding GO:0034714 ISS     deubiquitinase activator activity GO:0035800 IEA     deubiquitinase activator activity GO:0035800 ISO     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     protein serine/threonine kinase activator activity GO:0043539 IDA     protein-containing complex binding GO:0044877 IEA     protein-containing complex binding GO:0044877 ISO Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 IGI     cell morphogenesis GO:0000902 IDA     skeletal system development GO:0001501 TAS     vasculogenesis GO:0001570 IMP     ureteric bud development GO:0001657 IEP     morphogenesis of a branching structure GO:0001763 ISO     cell activation GO:0001775 IDA     epithelial to mesenchymal transition GO:0001837 ISO     epithelial to mesenchymal transition GO:0001837 ISO     epithelial to mesenchymal transition GO:0001837 ISO     epithelial to mesenchymal transition GO:0001837 ISS     neural tube closure GO:0001843 IMP     negative regulation of protein phosphorylation GO:0001933 ISO     regulation of sodium ion transport GO:0002028 IDA     sprouting angiogenesis GO:0002040 IEA     sprouting angiogenesis GO:0002040 ISO     chondrocyte differentiation GO:0002062 ISO     chondrocyte differentiation GO:0002062 ISS     columnar/cuboidal epithelial cell maturation GO:0002069 IMP     hematopoietic progenitor cell differentiation GO:0002244 ISO     hematopoietic progenitor cell differentiation GO:0002244 ISS     CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment GO:0002362 TAS     adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 IDA     tolerance induction to self antigen GO:0002513 IMP     negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 IEA     negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 ISO     heart valve morphogenesis GO:0003179 IMP     aortic valve morphogenesis GO:0003180 IMP     aortic valve morphogenesis GO:0003180 ISO     protein phosphorylation GO:0006468 IDA     protein phosphorylation GO:0006468 IGI     protein export from nucleus GO:0006611 IEA     protein export from nucleus GO:0006611 ISO     ATP biosynthetic process GO:0006754 ISO     ATP biosynthetic process GO:0006754 ISS     phosphate-containing compound metabolic process GO:0006796 ISO     phosphate-containing compound metabolic process GO:0006796 ISS     intracellular calcium ion homeostasis GO:0006874 IMP     defense response GO:0006952 TAS     inflammatory response GO:0006954 IMP     transforming growth factor beta receptor signaling pathway GO:0007179 IBA     transforming growth factor beta receptor signaling pathway GO:0007179 IDA     transforming growth factor beta receptor signaling pathway GO:0007179 IDA     transforming growth factor beta receptor signaling pathway GO:0007179 IMP     transforming growth factor beta receptor signaling pathway GO:0007179 ISO     Notch signaling pathway GO:0007219 IDA     negative regulation of neuroblast proliferation GO:0007406 IEA     negative regulation of neuroblast proliferation GO:0007406 ISO     salivary gland morphogenesis GO:0007435 ISS     endoderm development GO:0007492 IDA     heart development GO:0007507 IMP     skeletal muscle tissue development GO:0007519 TAS     female pregnancy GO:0007565 IEA     cell population proliferation GO:0008283 IDA     positive regulation of cell population proliferation GO:0008284 ISO     negative regulation of cell population proliferation GO:0008285 ISO     negative regulation of cell population proliferation GO:0008285 ISS     negative regulation of cell population proliferation GO:0008285 TAS     germ cell migration GO:0008354 IDA     response to xenobiotic stimulus GO:0009410 IEA     response to wounding GO:0009611 ISS     animal organ morphogenesis GO:0009887 TAS     gene expression GO:0010467 IDA     gene expression GO:0010467 IMP     regulation of gene expression GO:0010468 IDA     positive regulation of gene expression GO:0010628 IDA     positive regulation of gene expression GO:0010628 IDA     positive regulation of gene expression GO:0010628 IMP     positive regulation of gene expression GO:0010628 ISO     negative regulation of gene expression GO:0010629 IMP     negative regulation of gene expression GO:0010629 ISO     negative regulation of gene expression GO:0010629 ISO     negative regulation of gene expression GO:0010629 ISO     positive regulation of epithelial to mesenchymal transition GO:0010718 IDA     positive regulation of epithelial to mesenchymal transition GO:0010718 ISO     positive regulation of fibroblast migration GO:0010763 IMP     positive regulation of fibroblast migration GO:0010763 ISO     positive regulation of fibroblast migration GO:0010763 ISS     negative regulation of macrophage cytokine production GO:0010936 ISO     negative regulation of macrophage cytokine production GO:0010936 ISS     oligodendrocyte development GO:0014003 IMP     positive regulation of microglia differentiation GO:0014008 IMP     regulation of striated muscle tissue development GO:0016202 IDA     neural tube development GO:0021915 IMP     negative regulation of cell-cell adhesion GO:0022408 ISO     hyaluronan catabolic process GO:0030214 ISO     hyaluronan catabolic process GO:0030214 ISS     T cell differentiation GO:0030217 IMP     negative regulation of ossification GO:0030279 IDA     negative regulation of cell growth GO:0030308 IDA     negative regulation of cell growth GO:0030308 ISO     osteoclast differentiation GO:0030316 IDA     osteoclast differentiation GO:0030316 IGI     positive regulation of cell migration GO:0030335 ISO     positive regulation of cell migration GO:0030335 ISS     mammary gland development GO:0030879 IDA     animal organ regeneration GO:0031100 ISO     membrane protein intracellular domain proteolysis GO:0031293 ISO     membrane protein intracellular domain proteolysis GO:0031293 ISS     positive regulation of protein-containing complex assembly GO:0031334 ISO     positive regulation of protein-containing complex assembly GO:0031334 ISS     positive regulation of exit from mitosis GO:0031536 IEA     positive regulation of exit from mitosis GO:0031536 ISO     response to estradiol GO:0032355 ISO     response to estradiol GO:0032355 ISS     response to progesterone GO:0032570 ISO     response to progesterone GO:0032570 ISS     regulation of interleukin-23 production GO:0032667 IDA     negative regulation of interleukin-17 production GO:0032700 IDA     positive regulation of interleukin-17 production GO:0032740 IDA     positive regulation of interleukin-17 production GO:0032740 ISO     positive regulation of interleukin-6 production GO:0032755 IEA     positive regulation of interleukin-6 production GO:0032755 ISO     positive regulation of interleukin-6 production GO:0032755 ISO     positive regulation of tumor necrosis factor production GO:0032760 IEA     positive regulation of tumor necrosis factor production GO:0032760 ISO     receptor catabolic process GO:0032801 ISO     receptor catabolic process GO:0032801 ISS     regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0032829 TAS     positive regulation of superoxide anion generation GO:0032930 ISO     positive regulation of superoxide anion generation GO:0032930 ISS     mononuclear cell proliferation GO:0032943 IMP     regulation of actin cytoskeleton organization GO:0032956 IGI     positive regulation of collagen biosynthetic process GO:0032967 IDA     positive regulation of collagen biosynthetic process GO:0032967 ISO     response to vitamin D GO:0033280 IEA     response to laminar fluid shear stress GO:0034616 IEA     response to immobilization stress GO:0035902 IEA     T cell proliferation GO:0042098 IMP     T cell activation GO:0042110 IDA     T cell activation GO:0042110 IMP     T cell activation GO:0042110 IMP     regulation of cell population proliferation GO:0042127 IBA     regulation of cell population proliferation GO:0042127 IDA     negative regulation of T cell proliferation GO:0042130 IMP     regulation of protein import into nucleus GO:0042306 IDA     positive regulation of protein import into nucleus GO:0042307 ISO     positive regulation of protein import into nucleus GO:0042307 ISS     odontogenesis of dentin-containing tooth GO:0042475 IEA     positive regulation of odontogenesis GO:0042482 IDA     myelination GO:0042552 IEA     myelination GO:0042552 ISO     T cell homeostasis GO:0043029 IMP     positive regulation of apoptotic process GO:0043065 ISO     positive regulation of vascular permeability GO:0043117 IEA     positive regulation of vascular permeability GO:0043117 ISO     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO     surfactant homeostasis GO:0043129 IDA     surfactant homeostasis GO:0043129 IMP     positive regulation of MAPK cascade GO:0043410 ISO     positive regulation of blood vessel endothelial cell migration GO:0043536 ISO     positive regulation of blood vessel endothelial cell migration GO:0043536 ISS     negative regulation of blood vessel endothelial cell migration GO:0043537 ISO     negative regulation of blood vessel endothelial cell migration GO:0043537 ISS     regulatory T cell differentiation GO:0045066 IDA     regulatory T cell differentiation GO:0045066 IMP     regulatory T cell differentiation GO:0045066 ISO     cell-cell junction organization GO:0045216 ISO     cell-cell junction organization GO:0045216 ISS     regulation of regulatory T cell differentiation GO:0045589 IGI     positive regulation of regulatory T cell differentiation GO:0045591 IMP     negative regulation of fat cell differentiation GO:0045599 ISO     negative regulation of fat cell differentiation GO:0045599 ISS     negative regulation of myoblast differentiation GO:0045662 ISO     negative regulation of myoblast differentiation GO:0045662 ISS     positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 ISO     positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 ISS     negative regulation of cell cycle GO:0045786 ISO     negative regulation of cell cycle GO:0045786 ISS     negative regulation of DNA-templated transcription GO:0045892 ISO     negative regulation of DNA-templated transcription GO:0045892 ISS     positive regulation of DNA-templated transcription GO:0045893 IDA     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IGI     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     muscle cell cellular homeostasis GO:0046716 IGI     positive regulation of fibroblast proliferation GO:0048146 IDA     lung alveolus development GO:0048286 IDA     positive regulation of isotype switching to IgA isotypes GO:0048298 ISO     positive regulation of isotype switching to IgA isotypes GO:0048298 ISS     lymph node development GO:0048535 IMP     digestive tract development GO:0048565 IEA     negative regulation of skeletal muscle tissue development GO:0048642 ISO     negative regulation of skeletal muscle tissue development GO:0048642 ISS     positive regulation of smooth muscle cell proliferation GO:0048661 IEA     positive regulation of smooth muscle cell proliferation GO:0048661 ISO     inner ear development GO:0048839 IEA     epithelial cell proliferation GO:0050673 IDA     positive regulation of epithelial cell proliferation GO:0050679 IEA     positive regulation of epithelial cell proliferation GO:0050679 ISO     negative regulation of epithelial cell proliferation GO:0050680 ISO     negative regulation of epithelial cell proliferation GO:0050680 ISS     positive regulation of protein secretion GO:0050714 ISO     positive regulation of protein secretion GO:0050714 ISS     positive regulation of inflammatory response GO:0050729 IEA     positive regulation of inflammatory response GO:0050729 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     negative regulation of phagocytosis GO:0050765 IEA     negative regulation of phagocytosis GO:0050765 ISO     defense response to fungus GO:0050832 IEA     defense response to fungus GO:0050832 ISO     negative regulation of T cell activation GO:0050868 IMP     positive regulation of chemotaxis GO:0050921 ISO     positive regulation of chemotaxis GO:0050921 ISS     regulation of binding GO:0051098 IDA     regulation of DNA binding GO:0051101 IDA     positive regulation of smooth muscle cell differentiation GO:0051152 ISO     positive regulation of protein metabolic process GO:0051247 ISO     positive regulation of protein metabolic process GO:0051247 ISS     negative regulation of release of sequestered calcium ion into cytosol GO:0051280 IEA     negative regulation of release of sequestered calcium ion into cytosol GO:0051280 ISO     neuron apoptotic process GO:0051402 IDA     regulation of cell cycle GO:0051726 IDA     positive regulation of cell division GO:0051781 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     ventricular cardiac muscle tissue morphogenesis GO:0055010 IMP     phospholipid homeostasis GO:0055091 IDA     phospholipid homeostasis GO:0055091 IMP     canonical Wnt signaling pathway GO:0060070 IDA     face morphogenesis GO:0060325 IEP     frontal suture morphogenesis GO:0060364 IEA     positive regulation of SMAD protein signal transduction GO:0060391 IDA     positive regulation of SMAD protein signal transduction GO:0060391 ISO     positive regulation of SMAD protein signal transduction GO:0060391 ISS     bronchiole development GO:0060435 IDA     bronchiole development GO:0060435 IMP     mammary gland branching involved in thelarche GO:0060744 IMP     branch elongation involved in mammary gland duct branching GO:0060751 IMP     regulation of branching involved in mammary gland duct morphogenesis GO:0060762 IGI     regulation of cartilage development GO:0061035 IDA     retina vasculature development in camera-type eye GO:0061298 IDA     connective tissue development GO:0061448 IGI     Langerhans cell differentiation GO:0061520 IMP     negative regulation of biomineral tissue development GO:0070168 IMP     negative regulation of biomineral tissue development GO:0070168 ISO     regulation of enamel mineralization GO:0070173 IMP     lens fiber cell differentiation GO:0070306 IMP     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS     leukocyte proliferation GO:0070661 TAS     response to cholesterol GO:0070723 ISO     response to cholesterol GO:0070723 ISS     cellular response to mechanical stimulus GO:0071260 IEA     cellular response to glucose stimulus GO:0071333 IEA     cellular response to growth factor stimulus GO:0071363 IDA     cellular response to low-density lipoprotein particle stimulus GO:0071404 IEA     cellular response to low-density lipoprotein particle stimulus GO:0071404 ISO     cellular response to hypoxia GO:0071456 IEA     cellular response to hypoxia GO:0071456 ISO     cellular response to ionizing radiation GO:0071479 IMP     cellular response to dexamethasone stimulus GO:0071549 IEA     cellular response to dexamethasone stimulus GO:0071549 ISO     cellular response to transforming growth factor beta stimulus GO:0071560 IDA     cellular response to transforming growth factor beta stimulus GO:0071560 ISO     positive regulation of mononuclear cell migration GO:0071677 IEA     positive regulation of mononuclear cell migration GO:0071677 ISO     odontoblast differentiation GO:0071895 IMP     stem cell proliferation GO:0072089 IDA     T-helper 17 cell lineage commitment GO:0072540 TAS     extracellular matrix assembly GO:0085029 IDA     extracellular matrix assembly GO:0085029 ISO     positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 IEA     positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 ISO     positive regulation of canonical Wnt signaling pathway GO:0090263 IEA     positive regulation of canonical Wnt signaling pathway GO:0090263 ISO     positive regulation of canonical Wnt signaling pathway GO:0090263 ISO     extrinsic apoptotic signaling pathway GO:0097191 ISO     extrinsic apoptotic signaling pathway GO:0097191 ISS     liver regeneration GO:0097421 IEA     cellular response to virus GO:0098586 IDA     negative regulation of hyaluronan biosynthetic process GO:1900126 ISO     negative regulation of hyaluronan biosynthetic process GO:1900126 ISS     positive regulation of protein localization to nucleus GO:1900182 IGI     positive regulation of protein localization to nucleus GO:1900182 ISO     positive regulation of extracellular matrix assembly GO:1901203 IDA     response to salt GO:1902074 IEA     positive regulation of mesenchymal stem cell proliferation GO:1902462 IEA     positive regulation of mesenchymal stem cell proliferation GO:1902462 ISO     negative regulation of miRNA transcription GO:1902894 IEA     negative regulation of miRNA transcription GO:1902894 ISO     positive regulation of miRNA transcription GO:1902895 IEA     positive regulation of miRNA transcription GO:1902895 ISO     negative regulation of protein localization to plasma membrane GO:1903077 IEA     negative regulation of protein localization to plasma membrane GO:1903077 ISO     positive regulation of vasculature development GO:1904018 IEA     positive regulation of vasculature development GO:1904018 ISO     positive regulation of receptor signaling pathway via STAT GO:1904894 IEA     positive regulation of receptor signaling pathway via STAT GO:1904894 ISO     regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905005 IMP     cellular response to acetaldehyde GO:1905641 IEA     cellular response to insulin-like growth factor stimulus GO:1990314 IEA     embryonic liver development GO:1990402 IMP     negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 ISS     positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 IEA     positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 ISO     positive regulation of endothelial cell apoptotic process GO:2000353 IEA     positive regulation of endothelial cell apoptotic process GO:2000353 ISO     positive regulation of primary miRNA processing GO:2000636 IEA     positive regulation of primary miRNA processing GO:2000636 ISO     positive regulation of stem cell proliferation GO:2000648 IDA     positive regulation of cardiac muscle cell differentiation GO:2000727 IEA     positive regulation of cardiac muscle cell differentiation GO:2000727 ISO Subcellular Localization     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     microvillus GO:0005902 ISO     microvillus GO:0005902 ISS     cell surface GO:0009986 ISO     cell surface GO:0009986 ISS     secretory granule GO:0030141 IEA     secretory granule GO:0030141 ISO     axon GO:0030424 IEA     axon GO:0030424 ISO     extracellular matrix GO:0031012 IDA     neuronal cell body GO:0043025 IEA     neuronal cell body GO:0043025 ISO     collagen-containing extracellular matrix GO:0062023 IEA     collagen-containing extracellular matrix GO:0062023 ISO     blood microparticle GO:0072562 ISS