Gene description for Tff2
Gene name trefoil factor 2 (spasmolytic protein 1)
Gene symbol Tff2
Other names/aliases SP
mSP
Species Mus musculus
 Database cross references - Tff2
ExoCarta ExoCarta_21785
Vesiclepedia VP_21785
Entrez Gene 21785
 Tff2 identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Tff2
Molecular Function
    CXCR4 chemokine receptor binding GO:0031723 IBA
    CXCR4 chemokine receptor binding GO:0031723 IDA
Biological Process
    gastric acid secretion GO:0001696 IMP
    cell population proliferation GO:0008283 IMP
    positive regulation of cell population proliferation GO:0008284 IGI
    positive regulation of cell population proliferation GO:0008284 IMP
    calcium-mediated signaling GO:0019722 IDA
    maintenance of gastrointestinal epithelium GO:0030277 IBA
    regulation of cell migration GO:0030334 IGI
    macrophage activation GO:0042116 IMP
    negative regulation of macrophage activation GO:0043031 IMP
    negative regulation of inflammatory response GO:0050728 IMP
    establishment of localization in cell GO:0051649 IMP
    negative regulation of gastric acid secretion GO:0060455 IBA
    negative regulation of gastric acid secretion GO:0060455 IMP
    chemokine-mediated signaling pathway GO:0070098 IBA
    chemokine-mediated signaling pathway GO:0070098 IGI
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IGI
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified Tff2 in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Tff2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tff2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here