Gene description for Pomt2
Gene name protein-O-mannosyltransferase 2
Gene symbol Pomt2
Other names/aliases A830009D15Rik
AW046274
Species Mus musculus
 Database cross references - Pomt2
ExoCarta ExoCarta_217734
Vesiclepedia VP_217734
Entrez Gene 217734
UniProt Q8BGQ4  
 Pomt2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Pomt2
Molecular Function
    mannosyltransferase activity GO:0000030 ISO
    mannosyltransferase activity GO:0000030 ISS
    dolichyl-phosphate-mannose-protein mannosyltransferase activity GO:0004169 IEA
Biological Process
    dentate gyrus development GO:0021542 IMP
    protein O-linked mannosylation GO:0035269 ISO
    protein O-linked mannosylation GO:0035269 ISS
    basement membrane organization GO:0071711 IMP
    reactive gliosis GO:0150103 IMP
    positive regulation of protein O-linked glycosylation GO:1904100 IEA
    positive regulation of protein O-linked glycosylation GO:1904100 ISO
Subcellular Localization
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    nucleolus GO:0005730 IEA
    nucleolus GO:0005730 ISO
    endoplasmic reticulum membrane GO:0005789 ISS
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Pomt2 in sEVs
1
Experiment ID 15
MISEV standards
✔
EM
Biophysical techniques
✔
CD63
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Pomt2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pomt2 is involved
PathwayEvidenceSource
Metabolism of proteins IEA Reactome
O-linked glycosylation IEA Reactome
Post-translational protein modification IEA Reactome





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