Gene description for Rps6ka1
Gene name	ribosomal protein S6 kinase polypeptide 1
Gene symbol	Rps6ka1
Other names/aliases	Mapkapk-1a Rsk Rsk-1 Rsk1 S6K-alpha-1 p90-Rsk1 p90Rsk1 p90S6K p90rsk
Species	Mus musculus
Database cross references - Rps6ka1
ExoCarta	ExoCarta_20111
Vesiclepedia	VP_20111
Entrez Gene	20111
UniProt	P18653
Rps6ka1 identified in sEVs derived from the following tissue/cell type
Mast cells	11145662

Gene ontology annotations for Rps6ka1

Molecular Function     magnesium ion binding GO:0000287 IEA     protein serine/threonine kinase activity GO:0004674 ISO     protein serine/threonine kinase activity GO:0004674 ISS     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IBA     ribosomal protein S6 kinase activity GO:0004711 IEA     protein serine/threonine/tyrosine kinase activity GO:0004712 ISO     ATP binding GO:0005524 IEA     kinase activity GO:0016301 IDA     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 ISO     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     DNA-binding transcription factor binding GO:0140297 IPI     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 ISO     negative regulation of TOR signaling GO:0032007 ISO     intracellular signal transduction GO:0035556 IEA     TORC1 signaling GO:0038202 IBA     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of apoptotic process GO:0043066 ISS     positive regulation of DNA-templated transcription GO:0045893 IBA     positive regulation of DNA-templated transcription GO:0045893 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     hepatocyte proliferation GO:0072574 IDA     negative regulation of cysteine-type endopeptidase activity GO:2000117 ISO     positive regulation of hepatic stellate cell activation GO:2000491 ISO     positive regulation of hepatic stellate cell activation GO:2000491 ISS Subcellular Localization     nucleus GO:0005634 IEA     nucleoplasm GO:0005654 IBA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IEA     spindle GO:0005819 IDA     cytosol GO:0005829 ISO     synapse GO:0045202 EXP     synapse GO:0045202 IDA