Gene description for Rp2h
Gene name retinitis pigmentosa 2 homolog (human)
Gene symbol Rp2h
Other names/aliases AI662636
Rp2
Species Mus musculus
 Database cross references - Rp2h
ExoCarta ExoCarta_19889
Vesiclepedia VP_19889
Entrez Gene 19889
UniProt Q9EPK2  
 Rp2h identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rp2h
Molecular Function
    magnesium ion binding GO:0000287 IEA
    magnesium ion binding GO:0000287 ISO
    GTPase activator activity GO:0005096 IBA
    GTPase activator activity GO:0005096 ISO
    GTPase activator activity GO:0005096 ISS
    GTP binding GO:0005525 IEA
Biological Process
    post-Golgi vesicle-mediated transport GO:0006892 IBA
    post-Golgi vesicle-mediated transport GO:0006892 ISO
    post-chaperonin tubulin folding pathway GO:0007023 ISS
    protein transport GO:0015031 IEA
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    Golgi apparatus GO:0005794 IDA
    centriole GO:0005814 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    cilium GO:0005929 IBA
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
    cytoplasmic vesicle GO:0031410 ISO
    ciliary basal body GO:0036064 IDA
    ciliary basal body GO:0036064 ISO
    periciliary membrane compartment GO:1990075 IBA
    periciliary membrane compartment GO:1990075 IDA
 Experiment description of studies that identified Rp2h in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rp2h
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fancd2  
Affinity Capture-MS Mus musculus
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