Gene description for Reg3g
Gene name regenerating islet-derived 3 gamma
Gene symbol Reg3g
Other names/aliases AI449515
Species Mus musculus
 Database cross references - Reg3g
ExoCarta ExoCarta_19695
Vesiclepedia VP_19695
Entrez Gene 19695
UniProt O09049  
 Reg3g identified in sEVs derived from the following tissue/cell type
Faeces 33431899    
Faeces 33431899    
 Gene ontology annotations for Reg3g
Molecular Function
    hormone activity GO:0005179 IDA
    hormone activity GO:0005179 IMP
    signaling receptor activity GO:0038023 IBA
    peptidoglycan binding GO:0042834 IBA
    peptidoglycan binding GO:0042834 IDA
    peptidoglycan binding GO:0042834 ISO
    metal ion binding GO:0046872 IEA
    oligosaccharide binding GO:0070492 IBA
    oligosaccharide binding GO:0070492 IDA
    oligosaccharide binding GO:0070492 ISO
Biological Process
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 IMP
    acute-phase response GO:0006953 IEA
    positive regulation of cell population proliferation GO:0008284 IBA
    response to symbiotic bacterium GO:0009609 IDA
    response to wounding GO:0009611 IDA
    response to bacterium GO:0009617 IEP
    positive regulation of keratinocyte proliferation GO:0010838 IDA
    response to lipopolysaccharide GO:0032496 IDA
    response to peptide hormone GO:0043434 IBA
    negative regulation of keratinocyte differentiation GO:0045617 IDA
    negative regulation of inflammatory response GO:0050728 IDA
    defense response to Gram-negative bacterium GO:0050829 IDA
    defense response to Gram-positive bacterium GO:0050830 IDA
    defense response to Gram-positive bacterium GO:0050830 IMP
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IBA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 IDA
    antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 ISO
    positive regulation of wound healing GO:0090303 IDA
    negative regulation of inflammatory response to wounding GO:0106015 IDA
    positive regulation of detection of glucose GO:2000972 IMP
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 IDA
    secretory granule GO:0030141 IDA
    collagen-containing extracellular matrix GO:0062023 HDA
 Experiment description of studies that identified Reg3g in sEVs
1
Experiment ID 303
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
2
Experiment ID 304
MISEV standards
EM
Biophysical techniques
Cd63|Cd81|Cd9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33431899    
Organism Mus musculus
Experiment description High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors "Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG."
Journal name Nat Commun
Publication year 2021
Sample Faeces
Sample name Intestinal epithelial cells - C57BL/6
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Lipid
miRNA
Methods used in the study Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC
 Protein-protein interactions for Reg3g
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Reg3g is involved
PathwayEvidenceSource
Antimicrobial peptides IEA Reactome
Immune System IEA Reactome
Innate Immune System IEA Reactome





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