Gene description for Ptprc
Gene name protein tyrosine phosphatase, receptor type, C
Gene symbol Ptprc
Other names/aliases B220
CD45R
Cd45
L-CA
Ly-5
Lyt-4
T200
loc
Species Mus musculus
 Database cross references - Ptprc
ExoCarta ExoCarta_19264
Vesiclepedia VP_19264
Entrez Gene 19264
 Ptprc identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ptprc
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    protein tyrosine phosphatase activity GO:0004725 IDA
    protein tyrosine phosphatase activity GO:0004725 IGI
    protein tyrosine phosphatase activity GO:0004725 ISO
    protein tyrosine phosphatase activity GO:0004725 ISS
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    transmembrane receptor protein tyrosine phosphatase activity GO:0005001 IEA
    signaling receptor binding GO:0005102 IPI
    protein binding GO:0005515 IPI
    heparin binding GO:0008201 IDA
    protein kinase binding GO:0019901 IPI
    protein kinase binding GO:0019901 ISO
    protein kinase binding GO:0019901 ISS
    ankyrin binding GO:0030506 IEA
    ankyrin binding GO:0030506 ISO
    spectrin binding GO:0030507 IEA
    spectrin binding GO:0030507 ISO
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    heparan sulfate proteoglycan binding GO:0043395 IDA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    MAPK cascade GO:0000165 IMP
    natural killer cell differentiation GO:0001779 IMP
    negative regulation of T cell mediated cytotoxicity GO:0001915 IMP
    positive regulation of T cell mediated cytotoxicity GO:0001916 IMP
    negative regulation of cytokine-mediated signaling pathway GO:0001960 IDA
    hematopoietic progenitor cell differentiation GO:0002244 IEA
    hematopoietic progenitor cell differentiation GO:0002244 ISO
    positive regulation of immunoglobulin production GO:0002639 ISO
    positive regulation of T cell mediated immunity GO:0002711 IMP
    regulation of humoral immune response mediated by circulating immunoglobulin GO:0002923 IMP
    positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 IMP
    chromatin remodeling GO:0006338 IEA
    negative regulation of protein kinase activity GO:0006469 IDA
    negative regulation of protein kinase activity GO:0006469 ISO
    negative regulation of protein kinase activity GO:0006469 ISS
    protein dephosphorylation GO:0006470 IDA
    negative regulation of cell adhesion involved in substrate-bound cell migration GO:0006933 IEA
    negative regulation of cell adhesion involved in substrate-bound cell migration GO:0006933 ISO
    leukocyte cell-cell adhesion GO:0007159 IMP
    signal transduction GO:0007165 IBA
    response to gamma radiation GO:0010332 ISO
    regulation of gene expression GO:0010468 IGI
    regulation of gene expression GO:0010468 ISO
    dephosphorylation GO:0016311 IDA
    peptidyl-tyrosine phosphorylation GO:0018108 IMP
    B cell differentiation GO:0030183 IMP
    B cell differentiation GO:0030183 IMP
    T cell differentiation GO:0030217 IMP
    positive regulation of B cell proliferation GO:0030890 IMP
    positive regulation of B cell proliferation GO:0030890 ISO
    negative regulation of protein autophosphorylation GO:0031953 IMP
    regulation of interleukin-8 production GO:0032677 IEA
    regulation of interleukin-8 production GO:0032677 ISO
    negative regulation of interleukin-2 production GO:0032703 IGI
    positive regulation of interleukin-2 production GO:0032743 IGI
    positive regulation of tumor necrosis factor production GO:0032760 IGI
    heterotypic cell-cell adhesion GO:0034113 IMP
    T cell proliferation GO:0042098 IMP
    B cell proliferation GO:0042100 IMP
    B cell proliferation GO:0042100 IMP
    positive regulation of T cell proliferation GO:0042102 IMP
    gamma-delta T cell differentiation GO:0042492 IMP
    positive regulation of MAP kinase activity GO:0043406 IMP
    positive regulation of MAPK cascade GO:0043410 IGI
    positive regulation of MAPK cascade GO:0043410 IMP
    cell cycle phase transition GO:0044770 IEA
    cell cycle phase transition GO:0044770 ISO
    plasma membrane raft distribution GO:0044855 IGI
    positive thymic T cell selection GO:0045059 IMP
    negative thymic T cell selection GO:0045060 IMP
    positive regulation of T cell differentiation GO:0045582 IMP
    positive regulation of gamma-delta T cell differentiation GO:0045588 IMP
    regulation of receptor signaling pathway via JAK-STAT GO:0046425 ISO
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 IEA
    alpha-beta T cell proliferation GO:0046633 IMP
    positive regulation of alpha-beta T cell proliferation GO:0046641 IMP
    protein autophosphorylation GO:0046777 IMP
    positive regulation of isotype switching to IgG isotypes GO:0048304 IMP
    bone marrow development GO:0048539 IEA
    bone marrow development GO:0048539 ISO
    stem cell development GO:0048864 IEA
    stem cell development GO:0048864 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IGI
    negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 IMP
    regulation of phagocytosis GO:0050764 ISO
    positive regulation of phagocytosis GO:0050766 IGI
    positive regulation of calcium-mediated signaling GO:0050850 IGI
    T cell receptor signaling pathway GO:0050852 IGI
    T cell receptor signaling pathway GO:0050852 ISO
    T cell receptor signaling pathway GO:0050852 ISS
    B cell receptor signaling pathway GO:0050853 IMP
    B cell receptor signaling pathway GO:0050853 IMP
    regulation of T cell receptor signaling pathway GO:0050856 IGI
    positive regulation of antigen receptor-mediated signaling pathway GO:0050857 IMP
    release of sequestered calcium ion into cytosol GO:0051209 IDA
    defense response to virus GO:0051607 IDA
    defense response to virus GO:0051607 IMP
    regulation of cell cycle GO:0051726 IDA
    positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 IGI
    regulation of protein tyrosine kinase activity GO:0061097 ISO
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IGI
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IGI
    extrinsic apoptotic signaling pathway GO:0097191 IMP
    negative regulation of interleukin-4-mediated signaling pathway GO:1902215 IEA
    positive regulation of hematopoietic stem cell migration GO:2000473 IEA
    positive regulation of hematopoietic stem cell migration GO:2000473 ISO
    positive regulation of stem cell proliferation GO:2000648 IEA
    positive regulation of stem cell proliferation GO:2000648 ISO
    regulation of extrinsic apoptotic signaling pathway GO:2001236 IMP
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IMP
Subcellular Localization
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    focal adhesion GO:0005925 IDA
    external side of plasma membrane GO:0009897 IDA
    external side of plasma membrane GO:0009897 ISO
    cytoplasmic side of plasma membrane GO:0009898 NAS
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    bleb GO:0032059 IEA
    bleb GO:0032059 ISO
    membrane raft GO:0045121 IDA
    membrane raft GO:0045121 IGI
    synapse GO:0045202 IEA
    cell periphery GO:0071944 IDA
    membrane microdomain GO:0098857 IDA
 Experiment description of studies that identified Ptprc in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ptprc
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ints4  
Affinity Capture-MS Mus musculus
2 Tmem173  
Proximity Label-MS Mus musculus
3 Ptpre  
Affinity Capture-Western Mus musculus
4 Cap2  
Affinity Capture-MS Mus musculus
5 Ptprs 19280
Affinity Capture-Western Mus musculus
6 Atg16l1  
Affinity Capture-MS Mus musculus
7 Ptpra 19262
Affinity Capture-Western Mus musculus
8 Fancd2  
Affinity Capture-MS Mus musculus
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