Gene description for Ptpn1
Gene name	protein tyrosine phosphatase, non-receptor type 1
Gene symbol	Ptpn1
Other names/aliases	PTP-1B PTP-HA2 PTP1B
Species	Mus musculus
Database cross references - Ptpn1
ExoCarta	ExoCarta_19246
Vesiclepedia	VP_19246
Entrez Gene	19246
UniProt	P35821
Ptpn1 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Ptpn1

Molecular Function     protein tyrosine phosphatase activity GO:0004725 IDA     protein tyrosine phosphatase activity GO:0004725 IMP     protein tyrosine phosphatase activity GO:0004725 ISO     protein tyrosine phosphatase activity GO:0004725 ISS     protein tyrosine phosphatase activity GO:0004725 TAS     non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IBA     non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA     signaling receptor binding GO:0005102 ISO     insulin receptor binding GO:0005158 IEA     insulin receptor binding GO:0005158 ISO     zinc ion binding GO:0008270 IEA     zinc ion binding GO:0008270 ISO     phosphatase activity GO:0016791 ISO     enzyme binding GO:0019899 ISO     protein kinase binding GO:0019901 IBA     protein kinase binding GO:0019901 ISO     protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA     receptor tyrosine kinase binding GO:0030971 IEA     receptor tyrosine kinase binding GO:0030971 ISO     ephrin receptor binding GO:0046875 IEA     ephrin receptor binding GO:0046875 ISO     protein phosphatase 2A binding GO:0051721 IEA     protein phosphatase 2A binding GO:0051721 ISO     histone H2AXY142 phosphatase activity GO:0140793 IEA Biological Process     negative regulation of protein phosphorylation GO:0001933 ISO     positive regulation of systemic arterial blood pressure GO:0003084 IEA     positive regulation of systemic arterial blood pressure GO:0003084 ISO     chromatin remodeling GO:0006338 IEA     protein dephosphorylation GO:0006470 IMP     protein dephosphorylation GO:0006470 ISO     negative regulation of cell population proliferation GO:0008285 IEA     negative regulation of cell population proliferation GO:0008285 ISO     insulin receptor signaling pathway GO:0008286 IMP     regulation of signal transduction GO:0009966 ISO     regulation of signal transduction GO:0009966 ISS     positive regulation of heart rate GO:0010460 IEA     positive regulation of heart rate GO:0010460 ISO     positive regulation of cardiac muscle cell apoptotic process GO:0010666 IEA     positive regulation of cardiac muscle cell apoptotic process GO:0010666 ISO     negative regulation of cell-substrate adhesion GO:0010812 IEA     negative regulation of cell-substrate adhesion GO:0010812 ISO     negative regulation of neuron projection development GO:0010977 IEA     negative regulation of neuron projection development GO:0010977 ISO     actin cytoskeleton organization GO:0030036 ISO     actin cytoskeleton organization GO:0030036 ISS     regulation of endocytosis GO:0030100 ISO     regulation of endocytosis GO:0030100 ISS     regulation of proteolysis GO:0030162 IEA     regulation of proteolysis GO:0030162 ISO     negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 IGI     endoplasmic reticulum unfolded protein response GO:0030968 ISO     endoplasmic reticulum unfolded protein response GO:0030968 ISS     response to nutrient levels GO:0031667 IEA     regulation of intracellular protein transport GO:0033157 IEA     regulation of intracellular protein transport GO:0033157 ISO     response to endoplasmic reticulum stress GO:0034976 IMP     peptidyl-tyrosine dephosphorylation GO:0035335 IMP     peptidyl-tyrosine dephosphorylation GO:0035335 ISO     peptidyl-tyrosine dephosphorylation GO:0035335 ISS     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IMP     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 ISO     cellular response to platelet-derived growth factor stimulus GO:0036120 IEA     IRE1-mediated unfolded protein response GO:0036498 IMP     insulin receptor recycling GO:0038020 IMP     negative regulation of MAP kinase activity GO:0043407 ISO     positive regulation of JUN kinase activity GO:0043507 IMP     cellular response to fibroblast growth factor stimulus GO:0044344 IEA     regulation of insulin receptor signaling pathway GO:0046626 ISO     negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 ISO     negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IEA     negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISO     positive regulation of protein tyrosine kinase activity GO:0061098 ISO     negative regulation of ERK1 and ERK2 cascade GO:0070373 IBA     negative regulation of ERK1 and ERK2 cascade GO:0070373 IGI     cellular response to hypoxia GO:0071456 IEA     cellular response to nitric oxide GO:0071732 IEA     cellular response to nitric oxide GO:0071732 ISO     regulation of postsynapse assembly GO:0150052 IEA     regulation of hepatocyte growth factor receptor signaling pathway GO:1902202 IEA     regulation of hepatocyte growth factor receptor signaling pathway GO:1902202 ISO     negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 IMP     negative regulation of PERK-mediated unfolded protein response GO:1903898 IBA     negative regulation of PERK-mediated unfolded protein response GO:1903898 IMP     negative regulation of PERK-mediated unfolded protein response GO:1903898 ISO     cellular response to angiotensin GO:1904385 IEA     negative regulation of vascular associated smooth muscle cell migration GO:1904753 IEA     negative regulation of vascular associated smooth muscle cell migration GO:1904753 ISO     cellular response to nerve growth factor stimulus GO:1990090 IEA     cellular response to nerve growth factor stimulus GO:1990090 ISO     peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity GO:1990264 IGI     positive regulation of endothelial cell apoptotic process GO:2000353 IEA     positive regulation of endothelial cell apoptotic process GO:2000353 ISO     positive regulation of receptor catabolic process GO:2000646 IEA     positive regulation of receptor catabolic process GO:2000646 ISO Subcellular Localization     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     mitochondrial matrix GO:0005759 IEA     mitochondrial matrix GO:0005759 ISO     early endosome GO:0005769 IBA     early endosome GO:0005769 IDA     early endosome GO:0005769 ISO     early endosome GO:0005769 ISS     endoplasmic reticulum GO:0005783 IBA     endoplasmic reticulum GO:0005783 ISO     endoplasmic reticulum GO:0005783 NAS     cytosol GO:0005829 TAS     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISS     mitochondrial crista GO:0030061 IEA     mitochondrial crista GO:0030061 ISO     endosome lumen GO:0031904 IDA     protein-containing complex GO:0032991 ISO     sorting endosome GO:0097443 IDA     cytoplasmic side of endoplasmic reticulum membrane GO:0098554 IEA     cytoplasmic side of endoplasmic reticulum membrane GO:0098554 ISO     postsynapse GO:0098794 IEA     glutamatergic synapse GO:0098978 IEA